Active GMP Recombinant Human GDNF Protein

• Cat.No.: GDNF-01HG
• Product Overview: Recombinant human GDNF protein, was expressed in CHO-K1 cell-derived in an animal component free process under cGMP guidelines.

Specification

• Species: Human
• Source: CHO
• Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing.
• Form: Lyophilized powder
• Endotoxin: <20 EU/mg
• Bio-activity: >2.0 x 10^5 IU/mg
• Purity: >95.0% by high performance liquid chromatography (SEC-HPLC) and SDS-PAGE.
• Storage Buffer: 10mM Phosphate-Buffered Saline (pH 7.2)
• Storage: Stable storage at 4℃ for 7-10 days; for long-term storage, please store at -20℃ after dispensing.
• Sterility: Sterility
• Instructions: It is recommended that lyophilized GMP rhGDNF be dissolved in water for injection or sterilized ultrapure water at a concentration of not less than 100 μg/ml, pending further dilution to working concentration.

Gene Information

• Gene Name: GDNF glial cell derived neurotrophic factor [ Homo sapiens (human) ]
• Official Symbol: GDNF
• Synonyms: ATF; ATF1; ATF2; HSCR3; HFB1-GDNF
• Gene ID: 2668
• mRNA Refseq: NM_000514.4
• Protein Refseq: NP_000505.1
• UniProt ID: P39905
• MIM: 600837