XCR1
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Official Full Name
chemokine (C motif) receptor 1 -
Overview
The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
XCR1;chemokine (C motif) receptor 1;CCXCR1, chemokine (C motif) XC receptor 1 , GPR5;chemokine XC receptor 1;lymphotactin receptor;XC chemokine receptor 1;G protein-coupled receptor 5;G-protein coupled receptor 5;chemokine (C motif) XC receptor 1
Recombinant Proteins
- Human
- Chicken
- Mouse
- Mus musculus
- HEK293
- Mammalian Cells
- E.coli
- Chem-4
- Wheat Germ
- Non
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| XCR1-0182H |
Active Recombinant Human XCR1 Full Length Transmembrane protein(Nanodisc)
|
HEK293 | Human | Non | Full L. |
|
| XCR1-3497C | Recombinant Chicken XCR1 | Mammalian Cells | Chicken | His |
|
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| Xcr1-585M | Recombinant Mouse Xcr1 protein, His-tagged | E.coli | Mouse | His | Thr244~Tyr322 |
|
| XCR1-266HCL | Recombinant Human XCR1 293 Cell Lysate | HEK293 | Human | Non |
|
|
| CSC-RG0645 | Human XCR1/Galpha15 Stable Cell Line-Chem-4 | Chem-4 | Human | Non |
|
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| RFL11018MF | Recombinant Full Length Mouse Chemokine Xc Receptor 1(Xcr1) Protein, His-Tagged | E.coli | Mus musculus | His | Full L. Full Length (1-322) |
|
| RFL19172HF | Recombinant Full Length Human Chemokine Xc Receptor 1(Xcr1) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length (1-333) |
|
| XCR1-13HFL | Recombinant Full Length Human XCR1 Protein | Wheat Germ | Human | Full L. |
|
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| XCR1-5002M | XCR1 Antibody-coupled magnetic MicroBeads | Mouse |
|
Involved Pathway
XCR1 involved in several pathways and played different roles in them. We selected most pathways XCR1 participated on our site, such as Cytokine-cytokine receptor interaction,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with XCR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | GSK3A,BRAF,CCL25,VAV2,ROCK2,CCR5,GNG4,Adcy4,GNG8,PPBP |
| Cytokine-cytokine receptor interaction | IL12B,CCL17,TNFRSF18,GDF5,GH1,IL-15RA,IL13,FAS,IL1R1,Il23a; Il12b |
Protein Function
XCR1 has several biochemical functions, for example, chemokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by XCR1 itself. We selected most functions XCR1 had, and list some proteins which have the same functions with XCR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| chemokine receptor activity | CCR6A,CCR12A,CX3CR1,GPR17,CXCR3,CXCR3.2,CCBP2,CCR3,CXCR4B,CXCR4A |
Interacting Protein
XCR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with XCR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of XCR1.
Resources
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References
- Fossum, E; Grodeland, G; et al. Vaccine molecules targeting Xcr1 on cross-presenting DCs induce protective CD8(+) T-cell responses against influenza virus. EUROPEAN JOURNAL OF IMMUNOLOGY 45:624-635(2015).
- Hartung, E; Becker, M; et al. Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1. JOURNAL OF IMMUNOLOGY 194:1069-1079(2015).
