WWTR1
-
Official Full Name
WW domain containing transcription regulator 1 -
Overview
Transcriptional coactivator which acts as a downstream regulatory target in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. WWTR1 enhances PAX8 and NKX2-1/TTF1-dependent gene activation. Regulates the nuclear accumulation of SMADS and has a key role in coupling them to the transcriptional machinery such as the mediator complex. Regulates embryonic stem-cell self-renewal, promotes cell proliferation and epithelial-mesenchymal transition. -
Synonyms
WWTR1;WW domain containing transcription regulator 1;WW domain-containing transcription regulator protein 1;DKFZp586I1419;TAZ;transcriptional coactivator with PDZ-binding motif;transcriptional co-activator with PDZ-binding motif;FLJ27004;FLJ45718
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- Flag
Involved Pathway
WWTR1 involved in several pathways and played different roles in them. We selected most pathways WWTR1 participated on our site, such as Hippo signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with WWTR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | YWHAE,WNT2B,NKD1,BMP6,TP73,LLGL1,PPP2R1A,ITGB2,FZD2,BMP2 |
Protein Function
WWTR1 has several biochemical functions, for example, protein binding,protein homodimerization activity,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by WWTR1 itself. We selected most functions WWTR1 had, and list some proteins which have the same functions with WWTR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | CSF1,SLC39A13,GOLGA5,HEYL,SLK,SMAD3,IKZF2,TYRP1,ERP29,LRRFIP1 |
| transcription corepressor activity | HOXC6,RUNX1T1,NCOR2,TBL1XR1A,CDX2,BCL11A,NR0B2,HAND1,TFAP2B,MXI1 |
| protein binding | ZBTB26,ZSCAN1,KIR2DL4,RPP38,MYCBP2,TLR13,KHDRBS2,SELPLG,RBM10,ADARB1 |
| transcription coactivator activity | ING4,ZSCAN1,TAF5L,TAF10,BRD7,ATXN7L3,IL31RA,RNF20,HINFP,MAML2 |
Interacting Protein
WWTR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with WWTR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of WWTR1.
YWHAE;LATS1;CTNNB1;WBP2;DVL2
Resources
Related Services
Related Products
References
- Ferguson, BW; Gao, XS; et al. The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding. BMC CANCER 13:-(2013).
- Chen, XLL; Chinchilla, P; et al. Patched-1 Proapoptotic Activity Is Downregulated by Modification of K1413 by the E3 Ubiquitin-Protein Ligase Itchy Homolog. MOLECULAR AND CELLULAR BIOLOGY 34:3855-3866(2014).
