VIP
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Official Full Name
vasoactive intestinal peptide -
Overview
Vasoactive intestinal peptide also known as the vasoactive intestinal polypeptide or VIP is a peptide hormone containing 29 amino acid residues that is produced in many tissues of vertebrates including the gut, pancreas and suprachiasmatic nuclei of the hypothalamus in the brain. VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. In humans, the vasoactive intestinal peptide is encoded by the VIP gene. -
Synonyms
VIP;vasoactive intestinal peptide;VIP peptides;PHM27;MGC13587
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Cattle
- Rat
- Zebrafish
- Wheat Germ
- E.coli
- Mammalian Cells
- HEK293
- Human Cells
- In Vitro Cell Free System
- Non
- His
- Avi&Fc&His
- GST
Involved Pathway
VIP involved in several pathways and played different roles in them. We selected most pathways VIP participated on our site, such as G alpha (s) signalling events,GPCR downstream signaling,Signal Transduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with VIP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling by GPCR | CCK,CRHB,VIP2,ANXA1B,EDNRAB,TAC3,GPR120,NPB,UTS2,PENKA |
| G alpha (s) signalling events | DRD5,NPS,PDE10A,RAMP3,GCGB,RAMP2,CALCA,CALCB,RXFP2B,ADCYAP1R1 |
| GPCR downstream signaling | ABHD6B,RGS18,RGS6,INSL5,VIP2,TRPC3,CCR1,OR52J3,TIAM2,SOUL4 |
| Signal Transduction | KISS1,ARHGAP29B,PYYA,DNER,KAL1,KREMEN2,ARHGEF16,EMR4,FABP11A,IFT88 |
Protein Function
VIP has several biochemical functions, for example, hormone activity,neuropeptide hormone activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VIP itself. We selected most functions VIP had, and list some proteins which have the same functions with VIP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GP1BB,SNRPA,LRRK2,URI1,STX12,FATE1,RTN4RL1B,POLD2,C22orf29,NAT2 |
| hormone activity | SST1.1,CSH2,CGA,SST,ADM,MLN,SST2,CALCA,AVP,GUCA2A |
| neuropeptide hormone activity | GRP,NTS,CORT,PRLH,PNOC,CALCB,NPPA,AVP,NPFF,PYYA |
Interacting Protein
VIP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VIP here. Most of them are supplied by our site. Hope this information will be useful for your research of VIP.
SGTA;DPP4;FAP;MEOX2;UBQLN4
Resources
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References
- Wilhelm, M; Lawrence, JJ; et al. Enteric plexuses of two choline-acetyltransferase transgenic mouse lines: Chemical neuroanatomy of the fluorescent protein-expressing nerve cells. BRAIN RESEARCH BULLETIN 111:76-83(2015).
- Sand, E; Roth, B; et al. Structural and functional consequences of buserelin-induced enteric neuropathy in rat. BMC GASTROENTEROLOGY 14:-(2014).
