VCL
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Official Full Name
vinculin -
Overview
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008] -
Synonyms
VCL;vinculin;MV;MVCL;CMD1W;CMH15;HEL114;metavinculin;epididymis luminal protein 114
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Turkey
- Human Cells
- E.coli
- Mammalian Cells
- HEK293
- Turkey Smooth muscle
- His
- GST
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
VCL involved in several pathways and played different roles in them. We selected most pathways VCL participated on our site, such as Focal adhesion,Adherens junction,Leukocyte transendothelial migration, which may be useful for your reference. Also, other proteins which involved in the same pathway with VCL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Leukocyte transendothelial migration | PRKCA,RAC1,PTK2B,ACTG1,PRKCB,JAM2,ACTN4,CLDN5,CLDN4,ITGB1 |
| Adherens junction | ACTN2B,TCF7L2,RAC1,PARD3,NLK2,PTPRM,FYN,ACTN1,PTPRF,RHOAB |
| Bacterial invasion of epithelial cells | CBL,CDH1,SEPT1,PIK3R3,GAB1,CAV3,CBLB,SHC4,SHC2,HCLS1 |
| Regulation of Actin Cytoskeleton | MAP2K2,EZR,ITGA6,FGF18,PDGFC,CDC42L,PPP1R12C,PIP5K1A,FN1,MAPK3 |
| Focal adhesion | SRC,PIK3R3B,COL6A4,TNK1,PIK3CA,CAPN2B,ITGA3,ITGB3,COMP,ACTB1 |
| Amoebiasis | PRKCA,AASS,SERPINB10,COL1A2,LAMA3,ARG2,IL1R1,PLCB4,LAMB1,RELA |
| Shigellosis | NFKB1,WASF1,MAPK1,MAPK3,NFKBIB,ATG5,IKBKG,MAPK12,UBE2D2,ELMO3 |
Protein Function
VCL has several biochemical functions, for example, actin binding,NOT actin binding,alpha-catenin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by VCL itself. We selected most functions VCL had, and list some proteins which have the same functions with VCL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | APPL1,C19orf47,C7orf50,MED28,ALPP,HACE1,FLT3,PCOLCE,Itga10&Itgb1,ACSS1 |
| structural molecule activity | KRT82,SEPT4,CLDNJ,CLDN20,SPRR2G,ADD1,LMNA,CLDN19,CLDN2,LCE3E |
| beta-catenin binding | SLC9A3R1,GSK3B,KLF4,HDAC6,CARM1,LZTS2A,TCF7,DACT2,TBL1XR1,SMAD7 |
| alpha-catenin binding | CDH24,PKP2,PKP3,JUP,CDH2,JUB,JUPA,NUMB,AJUBA,CTNNB1 |
| actin binding | DNASE1,AVIL,CAPGA,UPF3B,GIPC1,MYH7B,WHAMM,INO80,EPB41L3B,NF2A |
| cadherin binding | CTNNA2,TBC1D2,TRPC4,PROM1,CD2AP,MMP24,P2RX4,CDK5R1,OLFM4,Fert2 |
| dystroglycan binding | MAP2,CLASP1,GYLTL1B,AGR2,AGRN,AGR3,DAG1,DMD |
| ubiquitin protein ligase binding | RALB,RBX1,LRPPRC,DNAJA1,USP13,ARRB2,CUL4A,YWHAE,SNCAIP,PPARGC1A |
Interacting Protein
VCL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VCL here. Most of them are supplied by our site. Hope this information will be useful for your research of VCL.
ipaA;Sorbs1;ipaA;TEKT1;TRIP6;VCAM1;TLN1
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References
- Liu, BJ; Tang, M; et al. Co-Incubation of Human Spermatozoa with Anti-VDAC Antibody Reduced Sperm Motility. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 33:142-150(2014).
- Puard, V; Tranchant, T; et al. Semi-quantitative measurement of specific proteins in human cumulus cells using reverse phase protein array. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY 11:-(2013).
