TYRP1
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Official Full Name
tyrosinase-related protein 1 -
Overview
This gene encodes a melanosomal enzyme that belongs to the tyrosinase family and plays an important role in the melanin biosynthetic pathway. Defects in this gene are the cause of rufous oculocutaneous albinism and oculocutaneous albinism type III. -
Synonyms
TYRP1;tyrosinase-related protein 1;CAS2, TYRP;5,6-dihydroxyindole-2-carboxylic acid oxidase;b PROTEIN;CATB;GP75;TRP;56 dihydroxyindole 2 carboxylic acid oxidase precursor;CAS2;Catalase B;DHICA oxidase;Glycoprotein 75;Melanoma antigen gp75;TRP1;Tyrosinase related protein 1;TYRP;TYRRP;TRP-1;OTTHUMP00000022788;b-PROTEIN
Recombinant Proteins
- Mouse
- Human
- Chicken
- Mus musculus
- HEK293
- E.coli
- Insect Cells
- Mammalian Cells
- Human Cells
- His
- Non
- DDK&Myc
- Avi&Fc&His
- Flag
Involved Pathway
TYRP1 involved in several pathways and played different roles in them. We selected most pathways TYRP1 participated on our site, such as Tyrosine metabolism,Metabolic pathways,Melanogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TYRP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tyrosine metabolism | TAT,HPDB,TH,GOT2,AOC2,ALDH3B2,AOX4,AOX3,AOC3,GOT2B |
| Melanogenesis | FZD10,GNAI2B,CALM3,WNT16,TCF7L2,PRKACBA,PRKACB,WNT2,MAP2K2A,PLCB2 |
| Metabolic pathways | H2-KE6,PPOX,CTH,UGT1A1,RRM2,COX8C,PIGU,CBSB,Acsm2a,DPM3 |
Protein Function
TYRP1 has several biochemical functions, for example, copper ion binding,oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TYRP1 itself. We selected most functions TYRP1 had, and list some proteins which have the same functions with TYRP1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | ZBTB16,BOKB,SETMAR,YARS2,TRIM8,PARK7,DAPK3,PTS,CUL3,UGT1A6B |
| copper ion binding | ATP7A,P2RX4,SLC11A2,SCO1,F5,F8,LOXL3B,COX11,DBH,AOC3 |
| protein binding | PGBD1,GLI3,THRA,RNF5,MORN4,GTF3C4,PAK4,TSPAN4,EDNRB,PEX16 |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen | TYRP1B |
| protein heterodimerization activity | HIST1H4L,HIST1H2AA,SMC3,UGT1A7,NR2C2,NFYBA,XBP1,SMC2,RALGAPA2,GUCY1A3 |
Interacting Protein
TYRP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TYRP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TYRP1.
GIPC1
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References
- Ghanem, G; Fabrice, J; et al. Tyrosinase related protein 1 (TYRP1/gp75) in human cutaneous melanoma. MOLECULAR ONCOLOGY 5:150-155(2011).
- Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
