TWIST1
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Official Full Name
twist homolog 1 (Drosophila) -
Overview
Twist1 is the basic helix-loop-helix transcription factor that regulates embryonic progenitor and transformed tumor cell proliferation, migration and differentiation and is also important in limb development. It has been shown that twist1 expression is high in patients suffering from rheumatic inflammatory disorders with chronically activated T helper lymphocytes and may be used as a biomarker for chronic t-cell activation. Mutations in twist1 are often associated with craniofacial and limb abnormalities in humans with Saethre-Chotzen syndrome. Twist1 dimer affinity can modify the DNA binding affinity. Twist1 has also been implicated as a promoter of tumor growth,Invasion and anti-cancer-drug resistance. -
Synonyms
TWIST1;twist homolog 1 (Drosophila);acrocephalosyndactyly 3 , ACS3, blepharophimosis, epicanthus inversus and ptosis 3 , BPES3, TWIST;twist-related protein 1;bHLHa38;BPES2;H twist;Saethre Chotzen syndrome;SCS;H-twist;B-HLH DNA binding protein;TWIST homolog of drosophila;class A basic helix-loop-helix protein 38;ACS3;CRS1;BPES3;TWIST
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- His&GST
- N-His-KSI
Involved Pathway
TWIST1 involved in several pathways and played different roles in them. We selected most pathways TWIST1 participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with TWIST1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | PPP1R12A,RPS6KB2,PPP1CB,THBS1,VTN,MAP2K1,PAK1,HGF,PIK3CD,ITGB5 |
Protein Function
TWIST1 has several biochemical functions, for example, E-box binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,bHLH transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TWIST1 itself. We selected most functions TWIST1 had, and list some proteins which have the same functions with TWIST1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | POU5F3,PKNOX1,HIST1H4I,CXCL13,FLOT2,VEGFB,ATF1,DRD1A,HIST3H3,TTR |
| E-box binding | BHLHE40,ASCL1,SREBF2,MYC,PER1,LMO2,ARNTL,ASCL2,TCF21,CLOCK |
| protein binding | SNRPN,C8orf4,NFKBID,TRIM39,WDR24,HSPBP1,WDFY3,BARHL2,PIK3R4,ZBTB26 |
| transcription factor binding | EGR1,PSMC5,PSMD10,PITX2,BRD7,MAFB,RB1,BCOR,MED12,CDK9 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXC1,FOXP3,SIM1A,MKX,SOX14,LYL1,FEV,SIM1B,FOXI2,ETV4 |
| bHLH transcription factor binding | BHLHE40,TCF3B,USF2,TCF3A,USF1,LMO2,PSMD9,MAP3K10,SMAD3,SIRT1 |
| protein homodimerization activity | GREM2,NETO2,BNIP3,SLC39A13,BMPR1A,ENO2,MAP3K9,CADM3,EFR3A,JUP |
| protein domain specific binding | NFE2L2,DDX6,LAMP1,AKAP1,DICER1,MLF1,CALM3,ARRB2,GABRR1,WNT3A |
Interacting Protein
TWIST1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TWIST1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TWIST1.
TP53;HIST2H4B;SETD8
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References
- Song, H; Kim, TO; et al. Intratumoral heterogeneity impacts the response to anti-neu antibody therapy. BMC CANCER 14:-(2014).
- Gilje, B; Nordgard, O; et al. Comparison of molecular and immunocytochemical methods for detection of disseminated tumor cells in bone marrow from early breast cancer patients. BMC CANCER 14:-(2014).
