TUBB3
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Official Full Name
tubulin, beta 3 class III -
Overview
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6. -
Synonyms
TUBB3;tubulin, beta 3 class III;tubulin, beta 3;tubulin beta-3 chain;beta 4;class III beta tubulin;tubulin beta-III;tubulin beta-4 chain;class III beta-tubulin;CDCBM;TUBB4;beta-4;CFEOM3A
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian cells
- Mammalian Cell
- HEK293
- E. coli
- HEK293T
- GST
- Flag
- His&GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
Involved Pathway
TUBB3 involved in several pathways and played different roles in them. We selected most pathways TUBB3 participated on our site, such as Delta-Notch Signaling Pathway,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TUBB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | MFAP2,DTX1,DNER,JAG1B,CTBP1,APH1C,EP300,RFNG,MARK2,YY1 |
| Delta-Notch Signaling Pathway | JAG2,TLE1,JAG1,CNTN1B,CNTF,HES6,TCF3B,WDR12,ADAM10A,MAGEA1 |
| NOTCH1 Intracellular Domain Regulates Transcription | TLE2,TLE1,HEYL,HEY1,HEY2,TLE4,TLE3 |
| Generic Transcription Pathway | ZNF257,ZNF561,ZNF227,ZNF461,CCNT2B,ZFP37,NR1D2B,ZFP90,ZNF263,NR2C2 |
| Gene Expression | COX4I1,ZMAT5,ZIK1,AGO3B,NR2C1,NR5A1,DARS,SAP18,GTF3AA,TTC6 |
Protein Function
TUBB3 has several biochemical functions, for example, peptide antigen binding,protein kinase binding,transcription coactivator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TUBB3 itself. We selected most functions TUBB3 had, and list some proteins which have the same functions with TUBB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein kinase binding | CCNB3,PPP1R12C,CD8A,MAP3K2,TRAF3,GDF3,GRB2,FAF1,CD4,ACVRL1 |
| peptide antigen binding | CD209,HLA-DRB1,MR1,AZGP1,MHC1UIA,MHC1UHA,HLA-E,DHCR24,MHC1UDA,BF2 |
| transcription coactivator activity | NPM1,NCOA1,CCNE1,PML,GABPA,MAX,PQBP1,JUND,PIAS2,MED12 |
Interacting Protein
TUBB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TUBB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TUBB3.
TUBA1B;TERF1;LRRK2;MAP3K3;TK1;RCC1;ANXA7;CDKN1A;TPTE;SMN1;15-deoxy-delta(12,14;midostaurin;ere_dna;SYNCRIP;PEX14
Resources
Research Area
Early Ectodermal Lineage MarkersNeuronal Lineage Markers
Microtubules
Ectodermal Lineage Markers
Related Services
Related Products
References
- Zen, Y; Britton, D; et al. Tubulin beta-III: a novel immunohistochemical marker for intrahepatic peripheral cholangiocarcinoma. HISTOPATHOLOGY 65:784-792(2014).
- Jouhilahti, EM; Visnapuu, V; et al. Oral soft tissue alterations in patients with neurofibromatosis. CLINICAL ORAL INVESTIGATIONS 16:551-558(2012).
