TRPV6
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Official Full Name
transient receptor potential cation channel, subfamily V, member 6 -
Overview
This gene encodes a member of a family of multipass membrane proteins that functions as calcium channels. The encoded protein contains N-terminal ankyrin repeats, which are required for channel assembly and regulation. This gene is situated next to a closely related gene for transient receptor potential cation channel subfamily V member 5 (TRPV5). This locus has experienced positive selection in non-African populations, resulting in several non-synonymous codon differences among individuals of different genetic backgrounds. [provided by RefSeq, Jul 2013] -
Synonyms
TRPV6;transient receptor potential cation channel, subfamily V, member 6;CAT1;CATL;ZFAB;ECAC2;ABP/ZF;LP6728;HSA277909;transient receptor potential cation channel subfamily V member 6;calcium transport protein 1;epithelial calcium channel 2;calcium transporter-like protein;Alu-binding protein with zinc finger domain;epithelial apical membrane calcium transporter/channel CaT1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mus musculus
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Flag
Involved Pathway
TRPV6 involved in several pathways and played different roles in them. We selected most pathways TRPV6 participated on our site, such as Salivary secretion,Mineral absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRPV6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Mineral absorption | MT2A,MT1,CYBRD1,FTL,MT1A,ATP1A2,MT1H,SLC31A1,ATP2B1,ATP1B2 |
| Salivary secretion | PRKCB,Adcy4,MUC5B,KCNN4,CALM2,PRKACG,PRKACB,PLCB2,RYR3,PLCB4 |
Protein Function
TRPV6 has several biochemical functions, for example, calcium channel activity,calmodulin binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRPV6 itself. We selected most functions TRPV6 had, and list some proteins which have the same functions with TRPV6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium channel activity | TRPV1,CACNB2,TRPN1,CACNG2B,CACNA1DA,CACNA1BA,PKD1,TMEM37,RYR2,SLC24A4 |
| calmodulin binding | MARCKSL1B,ATP2B1,EPB41B,VAMP2,MYO1A,CNN1A,NOS2,PHKB,CALD1,CAMK1 |
| protein binding | SLX1B,RBFOX1,ARRB2,CCT2,VPS28,REG3A,XRCC6,FTCD,GHRL,TRPC6 |
Interacting Protein
TRPV6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRPV6 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRPV6.
PTPN1;CALB1
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References
- Jeon, JP; Lee, KP; et al. The specific activation of TRPC4 by Gi protein subtype. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 377:538-543(2008).
- Hirnet, D; Olausson, J; et al. The TRPV6 gene, cDNA and protein. CELL CALCIUM 33:509-518(2003).
- Kennedy, BG; Torabi, AJ; et al. Expression of transient receptor potential vanilloid channels TRPV5 and TRPV6 in retinal pigment epithelium. MOLECULAR VISION 16:665-675(2010).
- Hdud, IM; El-Shafei, AA; et al. Expression of Transient Receptor Potential Vanilloid (TRPV) Channels in Different Passages of Articular Chondrocytes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 13:4433-4445(2012).
