TPMT
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Official Full Name
thiopurine S-methyltransferase -
Overview
This gene encodes the enzyme that metabolizes thiopurine drugs via S-adenosyl-L-methionine as the S-methyl donor and S-adenosyl-L-homocysteine as a byproduct. Thiopurine drugs such as 6-mercaptopurine are used as chemotherapeutic agents. Genetic polymorphisms that affect this enzymatic activity are correlated with variations in sensitivity and toxicity to such drugs within individuals. A pseudogene for this locus is located on chromosome 18q. -
Synonyms
TPMT;thiopurine S-methyltransferase;S-adenosyl-L-methionine:thiopurine S-methyltransferase
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- Mouse
- HEK293T
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
TPMT involved in several pathways and played different roles in them. We selected most pathways TPMT participated on our site, such as Drug metabolism - other enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TPMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Drug metabolism - other enzymes | CYP2A6,XDH,PNAT3,GUSB,CES1,GMPS,UGT1A3,UGT1A1,HPRT1,UGT1A7C |
Protein Function
TPMT has several biochemical functions, for example, thiopurine S-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TPMT itself. We selected most functions TPMT had, and list some proteins which have the same functions with TPMT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| thiopurine S-methyltransferase activity | TPMT.1,TPMT.2,OCLN |
Interacting Protein
TPMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TPMT here. Most of them are supplied by our site. Hope this information will be useful for your research of TPMT.
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References
- Leung, Y; Hanauer, SB; et al. Conventional treatment in inflammatory bowel disease- recent trends. Immunosuppressants and biologic agents: should they or need they to be used together?. GASTROENTEROLOGIE CLINIQUE ET BIOLOGIQUE 33:S202-S208(2009).
- Stassen, PM; Derks, RPH; et al. Thiopurinemethyltransferase (TPMT) genotype and TPMT activity in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: relation to azathioprine maintenance treatment and adverse effects. ANNALS OF THE RHEUMATIC DISEASES 68:758-759(2009).
