TNNC1
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Official Full Name
troponin C type 1 (slow) -
Overview
Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. -
Synonyms
tnnc1a;Cardiac troponin C;CMH7;cTnI;slow skeletal and cardiac muscles;Slow troponin C1;TN C;TN-C;TNC;TNNC 1;TNNC;TNNC1;TNNC1 protein;TNNC1_HUMAN;TNNI3;Troponin C;Troponin C cardiac;Troponin C slow;Troponin C slow skeletal and cardiac muscles;Troponin C type 1 (slow);Troponin C type 1;Troponin C1 slow;Troponin I type 3 (cardiac)
Recombinant Proteins
- Human
- Mouse
- Chicken
- E.coli
- Insect Cells
- Mammalian Cells
- HEK293
- Human Heart
- Insect cells
- GST
- Non
- His
- Flag
- DDK
- Myc
- Avi
- Fc
Involved Pathway
TNNC1 involved in several pathways and played different roles in them. We selected most pathways TNNC1 participated on our site, such as Calcium signaling pathway,Cardiac muscle contraction,Adrenergic signaling in cardiomyocytes, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNNC1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hypertrophic cardiomyopathy (HCM) | IGF1,TPM3,ITGA8,PRKAB2,PRKAA1,Itga10&Itgb1,SGCD,SLC8A1,CACNB1,TTN |
| Calcium signaling pathway | PRKACBA,RYR2,EDNRB,TACR3A,PDE1A,CACNA1H,HTR2A,CAMK2G1,ATP2A2B,TNNC2 |
| Adrenergic signaling in cardiomyocytes | CREB3L1,TPM4B,ATP1A3,CACNB4A,PIK3R3,CAMK2D,VMHC,ADRB3A,PRKACA,PIK3R5 |
| Dilated cardiomyopathy | SGCG,PRKACG,ITGB4,ITGA7,TPM3,PLN,ITGA2,DES,ACTG1,ITGB8 |
| Cardiac muscle contraction | COX4I2,CACNB3A,TNNC1B,SLC9A1,RYR2,UQCRC2B,TPM1,CACNG7,MYL4,CACNG2A |
Protein Function
TNNC1 has several biochemical functions, for example, actin filament binding,calcium ion binding,calcium-dependent protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNNC1 itself. We selected most functions TNNC1 had, and list some proteins which have the same functions with TNNC1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | CALCOCO2,MAP3K13,SUMF1,GNPTG,KCNN2,ABCG2,VPS4B,ACCS,HES1,WRN |
| troponin T binding | TNNT1,TNNI2,TNNI3 |
| metal ion binding | NUDT8,NCALDB,TET3,NRXN3A,ZFP652,PITPNM1,TRP63,CYP4V7,ZNF292B,ZFP668 |
| actin filament binding | LIMA1,ACTN2B,MYH9A,MYH10,MYO7A,SHROOM2,MYO1E,AJUBA,DBNLA,ACTN4 |
| calcium-dependent protein binding | CCDC167,ANXA2,NRXN1,ANXA6,S100P,MASP1,MYO5A,PDCD6IP,SYN1,ANXA7 |
| calcium ion binding | GCA,MYO5A,NUCB1,SLC25A25B,KIAA0494,PVALB8,MAN1A2,ACTN2B,EFCAB2,S100A2 |
| troponin I binding | RCAN3,TNNT3,TNNI3K |
Interacting Protein
TNNC1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNNC1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TNNC1.
Ppp1ca;Prkce;Ywhae
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References
- Tian, T; Wang, JZ; et al. A low prevalence of sarcomeric gene variants in a Chinese cohort with left ventricular non-compaction. HEART AND VESSELS 30:258-264(2015).
- Gomez, J; Reguero, JR; et al. Mutation Analysis of the Main Hypertrophic Cardiomyopathy Genes Using Multiplex Amplification and Semiconductor Next-Generation Sequencing. CIRCULATION JOURNAL 78:2963-U230(2014).
