TNFRSF11A
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Official Full Name
tumor necrosis factor receptor superfamily, member 11a -
Overview
Murine sRANK-Ligand or Soluble Receptor Activator of NF-κB Ligand, also known as Tumor Necrosis Factor Ligand Superfamily Member 11, is a 316 amino acid cytokine protein expressed from the Tnfsf11 gene located on chromosome 14. The peptide chain that exists from residue 1-36 is the membrane form of the RANK-Ligand while the chain that exists from residue 139-178 is the soluble form of the RANK-Ligand. The soluble form of isoform 1 derives from the membrane form by proteolytic processing. The cleavage may be catalyzed by ADAM17. The sRANK-Ligand is the cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK and acts as an osteoclast differentiation and activation factor. Moreover, the sRANK-Ligand homotrimer augments the ability of dendritic cells to stimulate naive T- cell proliferation, and thus may be an important regulator of interactions between T-cells and dendritic cells as well as T- cell-dependent immune responses. It is highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T-cells but not in B-cells; a high level expression is also seen in the trabecular bone and lung. Deficiency in Tnfsf11 results in failure to form lobulo-alveolar mammary structures during pregnancy, resulting in death of newborns. Trance-deficient mice show severe osteopetrosis, with no osteoclasts, marrow spaces, or tooth eruption, and exhibit profound growth retardation at several skeletal sites, including the limbs, skull, and vertebrae and have marked chondrodysplasia, with thick, irregular growth plates and a relative increase in hypertrophic chondrocytes. -
Synonyms
Ly109;ODFR;OFE;Rank;TRANCE-R;mRANK;osteoclast differentiation factor receptor;receptor activator of NF-KB;receptor activator of NF-kappaB;tumor necrosis factor receptor superfamily member 11A
Recombinant Proteins
- Human
- Mouse
- Rat
- Rhesus macaque
- Mus musculus
- HEK293
- Human Cell
- Mammalian cells
- Baculovirus
- Mammalian Cell
- Insect Cell
- E.coli
- E.coli expression system
- Human Cells
- Fc
- C-His&Fc
- His
- Non
- hIgG4
- His&Fc
- His&Fc&Avi
- GST
- mFc
- C-hFc-Flag
Involved Pathway
TNFRSF11A involved in several pathways and played different roles in them. We selected most pathways TNFRSF11A participated on our site, such as Cytokine-cytokine receptor interaction,NF-kappa B signaling pathway,Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNFRSF11A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | IL1B,LTA,TNFSF14,Ccl21c,SYK,PIDD1,MAP3K7,CCL4,IKBKB,NFKB1 |
| Prolactin signaling pathway | PIK3CB,GALT,STAT5A,MAPK12,PRP2,GSK3B,MAPK10,PRL,TNFSF11,ESR2 |
| Cytokine-cytokine receptor interaction | IFNAR2,TGFBR1,KDR,BMPR1BB,CRLF2,CCL4L2,CXCR7,TGFBR1B,TNFRSF17,INHBA |
| Osteoclast differentiation | IFNGR2,FCGR3,AKT2,IFNB1,PIK3CA,PPP3CA,STAT1,NFKB1,TGFBR2,LILRB5 |
| Rheumatoid arthritis | ICAM1,ATP6V1B1,ATP6V0D2,ATP6V0D1,TNF,HLA-DRB4,HLA-DRB1,TNFSF13B,TGFB1,ANGPT1 |
Protein Function
TNFRSF11A has several biochemical functions, for example, cytokine binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNFRSF11A itself. We selected most functions TNFRSF11A had, and list some proteins which have the same functions with TNFRSF11A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | LRP1,VMN1R40,VMN1R48,CD4,RET,GRIN1A,CD244,ATRN,ANXA2R,ITGB1B |
| protein binding | NOS1,SMAD9,CDC37,PRDX6,FBXO3,CCDC43,C7orf59,IL7R,ZNF230,LRRIQ3 |
| metal ion binding | SDF4,Scd2,ZBTB9,PRKRIR,ESCO1,ZNF559-ZNF177,CRYABA,HPX,DAGLB,CAR7 |
| transmembrane signaling receptor activity | SORL1,MPL,TLR2-1,SELE,GPR124,TLR4,CELSR1,CD27,CD69,IL27RA |
| cytokine binding | PARK7,LIFR,NRP1,CRLF1,Fzd4,CD74,CXCR4,IL17F,CNTFR,CHRD |
| tumor necrosis factor-activated receptor activity | CD40,TNFRSF10D,NRADD,TNFRSF10C,TNFRSF9,TNFRSF9A,HDR,EDA2R,RELT,TNFRSF8 |
Interacting Protein
TNFRSF11A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNFRSF11A here. Most of them are supplied by our site. Hope this information will be useful for your research of TNFRSF11A.
TMPRSS15;TRAF5;TRAF2;TRAF6
TNFRSF11A Related Signal Pathway
Resources
Research Area
Cytokine and Growth Factor Receptors on VSMCOsteoclast Markers
Inflammatory Mediators
Osteoblast and Osteoclast Markers
TNF Receptor
Related Services
Related Products
References
