TNC
-
Official Full Name
tenascin C -
Overview
Tenascins are extracellular matrix glycoproteins. They are abundant in the extracellular matrix of developing vertebrate embryos and they reappear around healing wounds and in the stroma of some tumors. -
Synonyms
Tenascin-X;tenascin XB1;tenascin XB2;OTTHUMP00000174881;tenascin XB;OTTHUMP00000216549;hexabrachion-like protein;growth-inhibiting protein 45;XB;TNX;XBS;HXBL;TENX;TN-X;TNXB1;TNXB2;TNXBS;TNXB
Recombinant Proteins
- Human
- Mouse
- Rat
- Rabbit
- Chicken
- Zebrafish
- Mammalian Cells
- E.coli
- Wheat Germ
- Human glioma cell line (U251)
- HEK293
- Insect Cells
- Yeast
- His
- Non
- DDK&Myc
- Avi&Fc&His
- His&Myc
- GST
- Flag
Involved Pathway
TNC involved in several pathways and played different roles in them. We selected most pathways TNC participated on our site, such as PIK-Akt signaling pathway,Focal adhesion,ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with TNC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | ARHGAP35,SEPP1,PRKCBB,MYL7,RAC3,IGF1RA,RAP1AA,PIK3CA,PIK3R3,ITGB3 |
| ECM-receptor interaction | COL4A3,Itga10&Itgb1,VTNB,THBS4B,THBS3,IBSP,ITGB8,COL4A2,SPP1,ITGA11A |
| PIK-Akt signaling pathway | PTK2,EPO,TCL1B4,GYS1,COL24A1,ITGA8,IFNA1,ITGA7,Reln,RPS6 |
| MicroRNAs in cancer | RAF1,SPRY2,Pdgfa&Pdgfb,THBS1,PLAU,WNT3,EP300,TRIM71,GRB2,ATM |
Protein Function
TNC has several biochemical functions, for example, syndecan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TNC itself. We selected most functions TNC had, and list some proteins which have the same functions with TNC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| syndecan binding | SDCBP,SEMA5A,HPSE,CHRD |
Interacting Protein
TNC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TNC here. Most of them are supplied by our site. Hope this information will be useful for your research of TNC.
Resources
Research Area
Mesenchymal Cells and EMTExtracellular Matrix Molecules
Skin Stem Cell Markers
Glioma Biomarkers
Other ECM Glycoproteins
Related Services
Related Products
References
- Pezzolo, A; Marimpietri, D; et al. Failure of anti tumor-derived endothelial cell immunotherapy depends on augmentation of tumor hypoxia. ONCOTARGET 5:10368-10381(2014).
- Alessio, GD; Cortes, DF; et al. Innovations in diagnosis and post-therapeutic monitoring of Chagas disease: Simultaneous flow cytometric detection of IgG1 antibodies anti-live amastigote, anti-live trypomastigote, and anti-fixed epimastigote forms of Trypanosoma cruzi. JOURNAL OF IMMUNOLOGICAL METHODS 413:32-44(2014).
