TMSB4X
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Official Full Name
thymosin beta 4, X-linked -
Overview
Thymosin beta-4 is a protein that in humans is encoded by the TMSB4X gene. The protein consists (in humans) of 44 amino acids (msdkpdmaei ekfdksklkk tetqeknplp sketieqekq ages) molWt 4921. This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. Thymosin beta-4 was shown to be essential for all aspects of coronary vessel development in mice; it stimulates significant outgrowth from quiescent adult epicardial explants, restoring pluripotency and triggering differentiation of fibroblasts, smooth muscle cells, and endothelial cells -
Synonyms
TMSB4X;FX;PTMB4;TB4X;TMSB4;thymosin beta 4, X-linked;OTTHUMP00000022927;prothymosin beta-4;thymosin, beta 4, X chromosome;thymosin beta-4;T beta-4;THYB4;Thymosin Beat 4
Recombinant Proteins
- Human
- Chicken
- Mouse
- Rhesus macaque
- Rat
- Zebrafish
- Horse
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&Fc&Avi
- His&SUMO
- Avi&His&Fc
- Myc&DDK
- Flag
Involved Pathway
TMSB4X involved in several pathways and played different roles in them. We selected most pathways TMSB4X participated on our site, such as Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with TMSB4X were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Regulation of Actin Cytoskeleton | ARHGEF6,IQGAP2,ROCK2A,MYL1,FGF4,ITGA10,MSNB,PIP5K2,FGF13B,ARPC5LA |
Protein Function
TMSB4X has several biochemical functions, for example, actin monomer binding,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TMSB4X itself. We selected most functions TMSB4X had, and list some proteins which have the same functions with TMSB4X. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
actin monomer binding | MKL1,ABL1,LIMA1,MYL3,TMSB4Y,PFN4,PKNOX2,TMSB,COBLL1,MKL1B |
protein binding | TOP3B,HIF1AN,GPATCH8,MSRB3,ZNF792,ISL1,EIF4EBP2,TFAP2A,FAM53C,C1orf105 |
poly(A) RNA binding | D19BWG1357E,NSUN5,LIN28B,PRPF3,MBNL3,ASS1,NSA2,POLR2A,SUGP1,POP1 |
Interacting Protein
TMSB4X has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TMSB4X here. Most of them are supplied by our site. Hope this information will be useful for your research of TMSB4X.
MLH1;SCHIP1;TK1;TP53;ANXA7
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References
- Yang, XR; Koltes, JE; et al. Gene Co-Expression Network Analysis Provides Novel Insights into Myostatin Regulation at Three Different Mouse Developmental Timepoints. PLOS ONE 10:-(2015).
- Lan, X; Li, DM; et al. Identification of differentially expressed genes related to metabolic syndrome induced with high-fat diet in E3 rats. EXPERIMENTAL BIOLOGY AND MEDICINE 240:235-241(2015).