TKT
-
Official Full Name
transketolase -
Overview
This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Multiple alternatively spliced variants, encoding the same protein, have been identified. -
Synonyms
TKT;transketolase;Wernicke Korsakoff syndrome;EC 2.2.1.1;FLJ34765;MS799;TK;TKT 1;TKT_HUMAN;TKT1;Transketolase (Wernicke Korsakoff syndrome);OTTHUMP00000212664;OTTHUMP00000212667;OTTHUMP00000212668
Recombinant Proteins
- Human
- Rat
- Mouse
- Durum wheat
- Bacillus subtilis
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- Mammalian cells
- E. coli or Yeast
- GST
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
TKT involved in several pathways and played different roles in them. We selected most pathways TKT participated on our site, such as Pentose phosphate pathway,Metabolic pathways,Carbon metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with TKT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Carbon metabolism | ENO1B,ACO2,TALDO1,EHHADH,GLDC,PDHB,HK2,DLD,PFKL,ACSS2L |
| Metabolic pathways | CYP51,B3GNT5,ACADVL,CEPT1,AANAT1,UAP1,GGT5,NDUFB9,ATP6V1G3,GPAT2 |
| Pentose phosphate pathway | ALDOA,GPIA,PGD,TKTL1,TKTL2,PFKMA,ALDOC,RPIA,PFKMB,H6PD |
| Biosynthesis of amino acids | ALDOCA,PAH,GPT2,GLUL,ENO1,IDH1,PFKM,IDH3G,PGAM1B,ACO2 |
Protein Function
TKT has several biochemical functions, for example, cofactor binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TKT itself. We selected most functions TKT had, and list some proteins which have the same functions with TKT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | DLX2,C9orf9,SMOC1,GBF1,AP1M1,ZNF180,LC3,GLP1R,FGF7,PSMB2 |
| metal ion binding | STEAP4,SDF4,PLRDGB,GM3258,ZFP27,Scd2,ZNF394,TRIM35-27,BMI1A,RHOV |
| cofactor binding | ACLYA,PGAM2,LMO2,PAH,PHYH,TYMS,HIF1AN,ACLY,DDO,ME3 |
| transketolase activity | TKTL1,TKTL2,TKTB |
| protein homodimerization activity | CBX5,MAOB,PARK7,RBM11,NR2C1,PFKM,ADRB2,HSP90AA1,GCA,PON3 |
Interacting Protein
TKT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TKT here. Most of them are supplied by our site. Hope this information will be useful for your research of TKT.
TERF1;EIF1B;GH1;MCC;HLA-B;VHL;GABARAPL2;YWHAZ;IKBKE;FBXO11;Bles03;ACTR6;ATG5;Csnk1e;TNFRSF10D;FTSJ1;accC1;bglA;smtA3
Resources
Related Services
Related Products
References
- Hartmannsberger, D; Mack, B; et al. Transketolase-like protein 1 confers resistance to serum withdrawal in vitro. CANCER LETTERS 300:20-29(2011).
- Mayer, A; von Wallbrunn, A; et al. Evidence against a Major Role for TKTL-1 in Hypoxic and Normoxic Cancer Cells. OXYGEN TRANSPORT TO TISSUE XXXII 701:123-128(2011).
