TIMP4
-
Official Full Name
TIMP metallopeptidase inhibitor 4 -
Overview
This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. The secreted, netrin domain-containing protein encoded by this gene is involved in regulation of platelet aggregation and recruitment and may play role in hormonal regulation and endometrial tissue remodeling. [provided by RefSeq, Jul 2008] -
Synonyms
TIMP4;TIMP metallopeptidase inhibitor 4;metalloproteinase inhibitor 4;TIMP-4;tissue inhibitor of metalloproteinase 4;tissue inhibitor of metalloproteinases 4
Recombinant Proteins
- Human
- Rhesus macaque
- Cattle
- Mouse
- Pig
- Rat
- Bovine
- E.coli
- CHO
- HEK293
- Mammalian Cell
- Yeast
- Mammalian cells
- GST
- His
- Fc
- Non
- His&T7
- His&GST
- His&Fc&Avi
- N-His-SUMO
Involved Pathway
TIMP4 involved in several pathways and played different roles in them. We selected most pathways TIMP4 participated on our site, such as Matrix Metalloproteinases, which may be useful for your reference. Also, other proteins which involved in the same pathway with TIMP4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Matrix Metalloproteinases | MMP19,MMP20,MMP12,MMP8,MMP23B,MMP24,MMP11,MMP27,MMP26,MMP17 |
Protein Function
TIMP4 has several biochemical functions, for example, metal ion binding,metalloendopeptidase inhibitor activity,protease binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TIMP4 itself. We selected most functions TIMP4 had, and list some proteins which have the same functions with TIMP4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protease binding | Casp3,C10orf2,SERPINB6,SERPINA1E,FN1,COMP,Serpina1c,SERPINB3,HSPA6,ITGA3 |
| metalloendopeptidase inhibitor activity | WFIKKN1,TIMP2,SPOCK3,TIMP3,RECK,TIMP2A,LXN,COL4A3,TIMP2B,WFIKKN2 |
| metal ion binding | GDPD3,TRPM6,DPEP3,ZFP828,ZFP36L3,ZNF613,LHX1A,LIG1,CYP2AA2,FHL2A |
Interacting Protein
TIMP4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TIMP4 here. Most of them are supplied by our site. Hope this information will be useful for your research of TIMP4.
Resources
Research Area
Angiogenesis InhibitorInflammatory Mediators
Metalloproteases and Regulators
Glioma Biomarkers
Angiogenesis Inhibitor in Cancer
Related Services
Related Products
References
