TFF3
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Official Full Name
trefoil factor 3 (intestinal) -
Overview
Trefoil factor 3 is a protein that in humans is encoded by the TFF3 gene. Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. This gene is expressed in goblet cells of the intestines and colon. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. -
Synonyms
TFF3;trefoil factor 3 (intestinal);trefoil factor 3;HITF;ITF;polypeptide P1.B;P1B;TFI
Recombinant Proteins
- Human
- Mouse
- Cattle
- Dog
- Pig
- Rat
- E.coli
- HEK293
- Human
- Yeast
- GST
- His
- His&Fc
- His&GST
- His&MBP
- Non
- Flag
- His&Myc
Involved Pathway
TFF3 involved in several pathways and played different roles in them. We selected most pathways TFF3 participated on our site, such as HIF-1-alpha transcription factor network,IL4-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL4-mediated signaling events | DOK2,IgG3,RETNLB,NIPAL1,MYB,EGR2,PARP14,IRF4,CCL26,MYBL1 |
| HIF-1-alpha transcription factor network | GATA2,ENG,CITED2,NPM1,CP,ADM,PLIN2,EGLN3,COPS5,NDRG1 |
Protein Function
TFF3 has several biochemical functions, for example, molecular_function,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFF3 itself. We selected most functions TFF3 had, and list some proteins which have the same functions with TFF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MYOZ1,DST,JOSD1,TREML2,LBX1,ALKBH6,NPHS1,MNDA,RTP3,NVL |
| molecular_function | HAUS4,TMEM107,GLIPR1B,ZC3H3,GLTPD2,FADS3,MUP11,CCDC71,GM14632,GRINAA |
Interacting Protein
TFF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of TFF3.
SGTA;PCBD1
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References
- Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
- Yue, L; Xiang, JY; et al. Inhibition of ErbB-2 induces TFF3 downregulation in breast cancer cell lines. APMIS 122:628-635(2014).
