TFAP2A

  • Official Full Name

    transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)

  • Overview

    The AP2 proteins are normally expressed in ectodermally derived vertebrate tissues where they are necessary for normal growth and development. The factors have also been implicated in the control of cell proliferation, viral transformation, and oncogenesis. AP2 seems to play in important role in human breast cancer. AP2 alpha is the only AP2 protein required for early morphogenesis of the lens vesicle. AP2 beta appears to be required for normal face and limb development and for proper terminal differentiation and function of renal tubular epithelia

  • Synonyms

    TFAP2A;transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha);AP2TF, TFAP2, transcription factor AP 2 alpha (activating enhancer binding protein 2 alpha);transcription factor AP-2-alpha;AP 2;AP2-alpha;activator protein 2;AP-

Recombinant Proteins

  • Human
  • Chicken
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cell
  • Wheat Germ
  • HEK293
  • HEK293T
  • Mammalian cells
  • His
  • Non
  • Myc&DDK
  • His&Fc&Avi
  • His&Myc
  • Flag
Cat.# Product name Source (Host) Species Tag Protein Length Price
TFAP2A-3351H Recombinant Human TFAP2A protein, His-tagged E.coli Human His 79-431 aa
TFAP2A-144H Recombinant Human TFAP2A Mammalian Cell Human His
TFAP2A-27355TH Recombinant Human TFAP2A Wheat Germ Human Non 107 amino acids
TFAP2A-6651C Recombinant Chicken TFAP2A Mammalian Cell Chicken His
TFAP2A-9570Z Recombinant Zebrafish TFAP2A Mammalian Cell Zebrafish His
TFAP2A-664HCL Recombinant Human TFAP2A lysate HEK293 Human Non
TFAP2A-1480H Recombinant Human TFAP2A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
TFAP2A-2176H Recombinant Human TFAP2A Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
TFAP2A-2176H-B Recombinant Human TFAP2A Protein Pre-coupled Magnetic Beads HEK293 Human
TFAP2A-2591M Recombinant Mouse TFAP2A Protein (1-437 aa), His-Myc-tagged E.coli Mouse His&Myc 1-437 aa
TFAP2A-402HFL Active Recombinant Full Length Human TFAP2A Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
Tfap2a-6374M Recombinant Mouse Tfap2a Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
TFAP2A-649H Recombinant Human TFAP2A Protein, MYC/DDK-tagged HEK293 Human Myc&DDK

    Involved Pathway

    TFAP2A involved in several pathways and played different roles in them. We selected most pathways TFAP2A participated on our site, such as Caspase cascade in apoptosis,Corticotropin-releasing hormone,Neural Crest Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TFAP2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Caspase cascade in apoptosis CFL2,PARP1,NUMA1,CRADD,CASP4,ACTA1,CASP2,DFFA,TOP1,LMNB1
    Neural Crest Differentiation LHX2,HEY2,OLIG2,HOXA1,TXLNB,PHOX2B,CDH7,DLL3,SOX10,OLIG3
    Corticotropin-releasing hormone CRHR2,CYP11A1,ADRBK2,TRIM28,IVL,JUND,TBX19,PARP1,KRT1,CASP12
    Wnt Signaling Pathway NetPath MAP1B,BCL9,BRD7,HIPK2,TCF4,MARK2,ANKRD6,NR5A1,CSNK2A1P,TAX1BP3

    Protein Function

    TFAP2A has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TFAP2A itself. We selected most functions TFAP2A had, and list some proteins which have the same functions with TFAP2A. You can find most of the proteins on our site.

    Function Related Protein
    protein dimerization activity SMG1,ATOH1A,NPAS2,EBF3A,HER9,DNM1,HNF1A,MNTB,POLR1D,USF1L
    protein binding S100A4,MYH9,LRRC75A-AS1,ZFYVE16,Car8,MPDZ,CYSLTR1,ZBTB17,TBL3,LGALS14
    sequence-specific DNA binding HOXB1A,CAMTA2,SCAND2P,AHR,LHX2B,POU3F1,FOXM1,ZNF263,HOXA9A,THRA
    transcription factor binding IRF4,TFDP1B,MAPK9,TBL1X,RNF19A,SOX17,SOST,INSIG2,NFATC4,ERCC3
    protein homodimerization activity CADM2,TFAP2E,HLA-G,SLC6A4,BOK,GSTZ1,SRGAP2,GRHPR,YARS2,OLIG2
    core promoter proximal region sequence-specific DNA binding DMRTC1C2,DMRT3,SMAD3,DMRT3A,CXXC1,SP3,GATA3,MEF2C,DMRT1,MIXL1
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding BCL11B,SIX4,MEF2A,MYC,TFAP2B,TP53,EGR1,SOX1,HOXA5,FOSB
    chromatin binding MEN1,PRMT6,ACTL6A,ANKRD17,PCNA,MSGN1,YBX2,TDRD3,NR5A1,CBX5
    transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding DDN,HIST2H3A,FOS,MSX1,ATF3,SREBF1,FOSB,RBPJB,CREB3,JDP2

    Interacting Protein

    TFAP2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TFAP2A here. Most of them are supplied by our site. Hope this information will be useful for your research of TFAP2A.

    UBE2I;NPM1;MKRN3;GSTO2;EP300

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