TBX5
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Official Full Name
T-box 5 -
Overview
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the;T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is;closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein;may play a role in heart development and specification of limb identity. Mutations in this gene have been associated;with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants;encoding different isoforms have been described for this gene. -
Synonyms
TBX5;T-box 5;HOS;T-box transcription factor TBX5;Holt Oram syndrome;T box 5;T box protein 5;T box transcription factor TBX 5;T box transcription factor TBX5;T-box protein 5;TBX 5;TBX5_HUMAN;Transcription factor T box 5;OTTHUMP00000232132;OTTHUMP00000232133;OTTHUMP00000232134;OTTHUMP00000232135
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- GST
- His
- Non
- Avi&Fc&His
- DDK&Myc
- His&Myc
- Flag
Involved Pathway
TBX5 involved in several pathways and played different roles in them. We selected most pathways TBX5 participated on our site, such as Cardiac Progenitor Differentiation,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TBX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Heart Development | NKX2-5,TBX20,FOXC1,HEY2,GATA6,SMYD1,HEY1,FOXH1,BMP10,IRX4 |
| YAP1- and WWTR1 (TAZ)-stimulated gene expression | TEAD3B,TEAD1A,TBX5A,HIPK1,NKX2 |
| Gene Expression | RDBP,ZNF75D,POLR3C,HNRNPA0,MAPKAPK2B,ZNF613,NR2F6A,EIF4B,POLRMT,EXOSC8 |
| Cardiac Progenitor Differentiation | NOG,IRX4,ROR2,SIRPA,ZFP42,SOX1,NKX2,LIN28A,NIPAL1,TBX20 |
| Generic Transcription Pathway | NR2E1,NR0B1,ZNF559,ZNF658,NR5A1,COX7C,ZNF606,ZNF597,ZNF254,ZNF567 |
Protein Function
TBX5 has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TBX5 itself. We selected most functions TBX5 had, and list some proteins which have the same functions with TBX5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor binding | SOX10,HDAC5,RORA,MED1,SMAD3,HES7,BPTF,POU5F1,HES3,FOS |
| sequence-specific DNA binding | FOXO3B,HOXB6,GATA2B,SFPI1,ARXA,HOXC8,HOXC6A,SCAND2P,HOXD3A,HOXA5A |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | RFX6,PAX9,BARHL1A,MAFBA,SOHLH1,MAFA,NKX2,GRHL3,LMO2,TP53 |
| transcription factor activity, sequence-specific DNA binding | TCF7,TBX5A,CBFA2T3,RORAA,ZNF238,RORAB,RBPJ,FOXH1,NFIA,ZKSCAN6 |
| RNA polymerase II regulatory region sequence-specific DNA binding | BARHL2,RUNX3,RXRB,HOXD8,ESRRG,CUX1,ONECUT3,FERD3L,ZNF79,NFIL3 |
| DNA binding | HMX4,GTF2I,KIAA0020,NFRKB,POLG,CHTF18,TSG101,MNDA,HOXB6A,KCNA3 |
| protein binding | MLC1,POU2F1,GTF3C6,ASB2,NDUFS3,CDK15,AUNIP,RAET1D,ANXA7,RRM2B |
Interacting Protein
TBX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TBX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of TBX5.
YAP1;tbe_human-dna;CTNNB1;Nkx2-5;Ctnnb1;Gata4;Wwtr1
Resources
Research Area
Cardiac Stem Cell MarkersOsteoclast Markers
Embryonic and Induced Pluripotent Stem Cell Markers
Osteoblast and Osteoclast Markers
Related Services
Related Products
References
- Jeon, JH; Suh, HN; et al. Glucosamine-Induced OGT Activation Mediates Glucose Production Through Cleaved Notch1 and FoxO1, Which Coordinately Contributed to the Regulation of Maintenance of Self-Renewal in Mouse Embryonic Stem Cells. STEM CELLS AND DEVELOPMENT 23:2067-2079(2014).
- Sandstedt, J; Jonsson, M; et al. SSEA-4+CD34-Cells in the Adult Human Heart Show the Molecular Characteristics of a Novel Cardiomyocyte Progenitor Population. CELLS TISSUES ORGANS 199:103-116(2014).
