TAT
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Official Full Name
tyrosine aminotransferase -
Overview
This nuclear gene encodes a mitochondrial protein tyrosine aminotransferase which is present in the liver and catalyzes the conversion of L-tyrosine into p-hydroxyphenylpyruvate. Mutations in this gene cause tyrosinemia (type II, Richner-Hanhart syndrome), a disorder accompanied by major skin and corneal lesions, with possible mental retardation. A regulator gene for tyrosine aminotransferase is X-linked. [provided by RefSeq, Jul 2008] -
Synonyms
TAT;tyrosine aminotransferase;tyrosine aminotransferase, cytosolic;L-tyrosine:2-oxoglutarate aminotransferase
Recombinant Proteins
- Human
- Mouse
- HIV
- Zebrafish
- Rat
- Human immunodeficiency virus 1
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293 cells
- HEK293T
- Mammalian cells
- His
- GST
- His&T7
- Non
- Myc&DDK
- E. coli
- His&Fc&Avi
- Flag
Involved Pathway
TAT involved in several pathways and played different roles in them. We selected most pathways TAT participated on our site, such as Ubiquinone and other terpenoid-quinone biosynthesis,Cysteine and methionine metabolism,Tyrosine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with TAT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquinone and other terpenoid-quinone biosynthesis | HPD,COQ3,HPDA,AMOTL1,GGCX,COQ5,COQ6,COQ7,HPDB,VKORC1L1 |
| Cysteine and methionine metabolism | MRI1,AHCYL2,MAT2AL,GSS,MAT2AA,IL4I1,GOT2A,LDHB,GOT2B,CBSA |
| Phenylalanine, tyrosine and tryptophan biosynthesis | GOT1,GOT2A,IL4I1,PAH,GOT2B,GOT2 |
| Biosynthesis of amino acids | PGAM1B,PC,PSPH,MAT2B,CTH,THA1,TALDO1,PSAT1,pykF,TKTL1 |
| Tyrosine metabolism | AOC2,HPD,ALDH1A3,HGD,COMTB,GOT1,TYRP1B,GOT2,HPDB,COMTA |
| Phenylalanine metabolism | PAH,ALDH3B2,ALDH3B1,HPDB,GOT2A,AOC2,GOT2B,ALDH3A1,HPDA,MAOB |
| Metabolic pathways | ACSL1,PTS,UPP1,ALDH3A2A,COX5B2,ACADVL,MGAT4B,PTGDS,ATP6V1BA,CES1C |
Protein Function
TAT has several biochemical functions, for example, L-phenylalanine:2-oxoglutarate aminotransferase activity,L-tyrosine:2-oxoglutarate aminotransferase activity,amino acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TAT itself. We selected most functions TAT had, and list some proteins which have the same functions with TAT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| pyridoxal phosphate binding | DDC,PYGB,ACCSL,CTH,AADAT,CBS,KYNU,SPTLC1,PROSC,PYGMB |
| L-phenylalanine:2-oxoglutarate aminotransferase activity | GOT2,GOT1,GOT2A,GOT2B |
| amino acid binding | DDAH2,TPH1A,TDO2,AARS2,DDC,GCHFR,TPH2,TPH1B,AGXT,PAH |
Interacting Protein
TAT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TAT here. Most of them are supplied by our site. Hope this information will be useful for your research of TAT.
Resources
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References
- Alanen, HI; Walker, KL; et al. Efficient export of human growth hormone, interferon alpha 2b and antibody fragments to the periplasm by the Escherichia coli Tat pathway in the absence of prior disulfide bond formation. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 1853:756-763(2015).
- Komarova, EY; Meshalkina, DA; et al. The discovery of Hsp70 domain with cell-penetrating activity. CELL STRESS & CHAPERONES 20:343-354(2015).
