SUB1
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Official Full Name
SUB1 SUB1 homolog (S. cerevisiae) -
Overview
The human PC4 (also called p15) is a non-TAF transcription coactivator that mediates activator-dependent transcription by RNA polymerase II in vitro through most tested activators. The function of PC4 is apparently through interactions with transcriptional activators and the basal transcription machinery. It is negatively regulated by casein kinase II phosphorylation both in vivo and in vitro. PC4 strongly binds single stranded DNA and regulates HSSB (RPA)-dependent SV40 DNA replication. Recent studies indicated that PC4 can be acetylated by several histone acetyltransferase. -
Synonyms
SUB1;SUB1 homolog (S. cerevisiae);activated RNA polymerase II transcriptional coactivator p15;p14;p15;PC4;positive cofactor 4;activated RNA polymerase II transcription cofactor 4;P15;MGC102747
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rhesus macaque
- Rat
- Cynomolgus
- E.coli
- Mammalian Cell
- E.Coli or Yeast
- HEK293
- Mammalian cells
- HEK293T
- GST
- Non
- His
- His&Fc&Avi
- Flag
- Myc&DDK
- His&SUMO
Involved Pathway
SUB1 involved in several pathways and played different roles in them. We selected most pathways SUB1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SUB1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SUB1 has several biochemical functions, for example, poly(A) RNA binding,protein binding,single-stranded DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SUB1 itself. We selected most functions SUB1 had, and list some proteins which have the same functions with SUB1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | ALKBH5,SPATS2L,EPPK1,RPS14,NSA2,PATL1,NOP56,TRA2A,CPEB4,TRIM25 |
| transcription coactivator activity | PQBP1,GABPA,TAF1,UTF1,ASXL1,MYSM1,RNF20,SMARCA2,LPIN1,ING4 |
| single-stranded DNA binding | RAD51AP1,TDP2B,CTC1,RAD51,WBP11,CNBP,SSBP4,OBFC1,PMS1,TREX1 |
| protein binding | RPGRIP1,ETS2,DPYSL2,GTF2E2,AP1M2,RECQL,ABLIM3,COMMD2,DAPK2,SYNPO2L |
| transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding | PROP1,PBX3,SIX6,ARID3B,FUBP1,NFE2L1,FOXH1,NFE2L2,REL,BACH1 |
Interacting Protein
SUB1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SUB1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SUB1.
CSNK2A1;tat_hv112;Rep68;CSTF2;Rep40;Kif1c;Shoc2;CSTF2;Rep78;PINX1;midostaurin
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