SPHK1
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Official Full Name
sphingosine kinase 1 -
Overview
The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] -
Synonyms
SPHK1;sphingosine kinase 1;SPHK;SK 1;SPK 1
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Sf9 Cells
- Insect Cells
- Sf21 Cells
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Fc
- Flag
- DDK
- Myc
- Avi
Involved Pathway
SPHK1 involved in several pathways and played different roles in them. We selected most pathways SPHK1 participated on our site, such as Sphingolipid metabolism,Metabolic pathways,Calcium signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SPHK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| VEGF signaling pathway | HSPB1,CDC42L2,PRKCB,MAP2K1,PXN,NOS3,MAPK12,CDC42L,RAF1,AKT1 |
| Sphingolipid signaling pathway | TNF,PLCB2,PLCB4,GAB2,MAPK3,FCER1G,HRAS,LOC100328615,S1PR5,PTEN |
| Phospholipase D signaling pathway | MAPK1,FYN,AKT1,MAP2K2,PRKCA,GRM4,PLA2G4F,Adcy4,AGPAT5,MAP2K1 |
| Fc gamma R-mediated phagocytosis | PIK3CB,PIK3R5,PPAP2C,NCF1,CFL2,ARF6,PIK3CA,PAK1,cgr2b,VAV3 |
| Metabolic pathways | ACADM,GAPDH,NDUFAB1,UROC1,HAAO,AADAT,GAD1B,GLDC,ATP6V0A1B,HYAL4 |
| Sphingolipid metabolism | DEGS1,SPHK2,FA2H,GLA,COL4A3BP,SPTLC2A,GALCB,OSBP,SMPD4,PPAP2A |
| Calcium signaling pathway | ERBB4,CAMK2D2,TACR3A,SLC25A4,SLC8A4A,CALM1,SPHK2,HTR2B,AGTR1,CACNA1SB |
| Tuberculosis | CASP9,RAF1,CLEC4E,NFYA,CD74,PPP3R1,STAT1,Ifna15,FADD,ATP6V1H |
Protein Function
SPHK1 has several biochemical functions, for example, ATP binding,D-erythro-sphingosine kinase activity,DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SPHK1 itself. We selected most functions SPHK1 had, and list some proteins which have the same functions with SPHK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase 2A binding | PPP2R2A,SMG5,PPP2R4,CPD,ARPP19,EIF4EBP1,STRN,ENSAA,GRIN3A,HMGCR |
| calmodulin binding | MARCKSA,KCNQ1,PLCB1,TRPC2,TTN,ATP2B4,GEM,MYH4,DAPK2,AEBP1 |
| sphinganine kinase activity | SPHK2 |
| magnesium ion binding | INPP1,IDH3A,NUDT18,PRPS1L1,FARS2,HPRT1L,RPS6KA5,ARF1,Atp8a2,NEK6 |
| sphingosine-1-phosphate receptor activity | S1PR3,S1PR5A,S1PR5B,S1PR5,S1PR2,S1PR4,S1PR1,GPR6,SPHK2,S1PR3A |
| DNA binding | SCMH1,ZFP367,CDAN1,TAF1A,DBX1B,ZFP827,ZNF276,TOMM20A,NKX6.3,NR5A1B |
| ATP binding | UHMK1,ABCE1,UBE2K,ANKK1,PAK2B,RIOK1,ABCA13,SMG1,SPATA5L1,NMNAT3 |
| protein binding | NEUROD1,BRCA1,HTATIP2,FABP3,PKD2L1,CYFIP2,HDDC2,PSEN1,TRIP4,FBXO45 |
| D-erythro-sphingosine kinase activity | SPHK2 |
Interacting Protein
SPHK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SPHK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SPHK1.
SPHKAP;EEF1A1;FHL2;FYN;CTSB;TRAF6
Resources
Research Area
Multiple Sclerosis and Myelin Related MoleculesIntracellular Kinases in the Akt Pathway
Fatty Acid Catabolism
Intracellular Signaling Molecules in Angiogenesis
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References
- Eberlein, C; Rooney, C; et al. E-Cadherin and EpCAM expression by NSCLC tumour cells associate with normal fibroblast activation through a pathway initiated by integrin alpha v beta 6 and maintained through TGF beta signalling. ONCOGENE 34:704-716(2015).
- Camare, C; Trayssac, M; et al. Oxidized LDL-induced angiogenesis involves sphingosine 1-phosphate: prevention by anti-S1P antibody. BRITISH JOURNAL OF PHARMACOLOGY 172:106-118(2015).
