SLPI
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Official Full Name
secretory leukocyte peptidase inhibitor -
Overview
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. [provided by RefSeq, Jul 2008] -
Synonyms
SLPI;secretory leukocyte peptidase inhibitor;ALP;MPI;ALK1;BLPI;HUSI;WAP4;WFDC4;HUSI-I;antileukoproteinase;HUSI-1;protease inhibitor WAP4;mucus proteinase inhibitor;seminal proteinase inhibitor;WAP four-disulfide core domain protein 4;secretory leukocyte protease inhibitor (antileukoproteinase)
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- Insect Cell
- HEK293
- E.coli
- E.Coli or Yeast
- Mammalian Cell
- HEK293T
- Mammalian cells
- His
- Fc
- Non
- His&Fc&Avi
- His&GST
- Myc&DDK
- His&Myc
- GST
- Flag
Involved Pathway
SLPI involved in several pathways and played different roles in them. We selected most pathways SLPI participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with SLPI were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
SLPI has several biochemical functions, for example, endopeptidase inhibitor activity,enzyme binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLPI itself. We selected most functions SLPI had, and list some proteins which have the same functions with SLPI. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| serine-type endopeptidase inhibitor activity | SPINK2,SPOCK1,WFDC6B,SERPINE1,SERPINB1L3,SERPINA3C,PEBP1,WFDC6,SERPINH1B,SPINK13 |
| endopeptidase inhibitor activity | SERPINA1D,UCHL5,C3P1,SPINT2,PI3,RENBP,SERPINF2,PSMF1,Hc,C3A.2 |
| enzyme binding | TSPYL1,TOP2B,PIAS1,CREB1,CASC3,HSPA6,DNM2,MSH3,CNTNAP2,H2AFX |
| protein binding | LRDD,FTCD,HOOK1,TARS,TRAPPC2,JUB,FBXO11,CYFIP1,PLP2,STRN |
Interacting Protein
SLPI has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLPI here. Most of them are supplied by our site. Hope this information will be useful for your research of SLPI.
SGTA;FAM9B;ELANE;NFKBIB;MAPK8IP2
Resources
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References
- Hirbod, T; Kong, XR; et al. HIV Acquisition Is Associated with Increased Antimicrobial Peptides and Reduced HIV Neutralizing IgA in the Foreskin Prepuce of Uncircumcised Men. PLOS PATHOGENS 10:-(2014).
- Woodham, AW; Da Silva, DM; et al. The S100A10 Subunit of the Annexin A2 Heterotetramer Facilitates L2-Mediated Human Papillomavirus Infection. PLOS ONE 7:-(2012).
