SLC7A11

  • Official Full Name

    solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11

  • Overview

    This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]

  • Synonyms

    SLC7A11;solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11;xCT;CCBR1;cystine/glutamate transporter;amino acid transport system xc-;solute carrier family 7 member 11;calcium channel blocker resistance protein CCBR1;solute carrier family 7, (cationic amino acid transporter, y+ system) member 11

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Mouse
  • HEK293
  • Wheat Germ
  • Mammalian Cells
  • E.coli
  • In Vitro Cell Free System
  • Non
  • GST
  • His
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
SLC7A11-49567H Active Recombinant Human SLC7A11 Full Length Transmembrane protein(Nanodisc) HEK293 Human Non Full L.
SLC7A11-30700TH Recombinant Human SLC7A11 protein, GST-tagged Wheat Germ Human GST 1-501 a.a.
SLC7A11-4311R Recombinant Rhesus monkey SLC7A11 Protein, His-tagged Mammalian Cells Rhesus macaque His
SLC7A11-1698HCL Recombinant Human SLC7A11 293 Cell Lysate HEK293 Human Non
RFL33376HF Recombinant Human Cystine/Glutamate Transporter(Slc7A11) Protein, His-Tagged E.coli Human His Full Length (1-501aa)
SLC7A11-01H Recombinant Human SLC7A11 Protein, His-tagged E.coli Human His
SLC7A11-11H Recombinant Human SLC7A11 Protein E.coli Human
Slc7a11-2080M Recombinant Mouse Slc7a11 Protein, His-tagged E.coli Mouse His Ala287-Pro365
SLC7A11-2957H Active Recombinant Human SLC7A11 Full Length Transmembrane protein, His-tagged E.coli Human His Full L. 1-501aa
SLC7A11-301337H Recombinant Human SLC7A11 protein, GST-tagged E.coli Human GST
SLC7A11-301456H Recombinant Human SLC7A11 protein, GST-tagged E.coli Human GST Met211-Thr265
SLC7A11-4127R Recombinant Rhesus Macaque SLC7A11 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
SLC7A11-4127R-B Recombinant Rhesus Macaque SLC7A11 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
SLC7A11-481HF Recombinant Full Length Human SLC7A11 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 501 amino acids
SLC7A11-6223H Recombinant Human SLC7A11 protein, His-tagged E.coli Human His
SLC7A11-6253H Recombinant Human SLC7A11 protein, His-tagged E.coli Human His

    Involved Pathway

    SLC7A11 involved in several pathways and played different roles in them. We selected most pathways SLC7A11 participated on our site, such as Amino acid transport across the plasma membrane,Basigin interactions,Cell surface interactions at the vascular wall, which may be useful for your reference. Also, other proteins which involved in the same pathway with SLC7A11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cell surface interactions at the vascular wall ESAMA,BSG,JAM2B,GRB7,SLC16A1,NADL1.1,AMICA1,FCER1GL,SIRPA,ITGB1B.1
    Basigin interactions SLC16A8,ITGB1B.1,SLC3A2B,BSG,PPIA,SLC7A6,NADL1.1,SLC3A2A,SLC7A8A,SLC16A1
    Amino acid transport across the plasma membrane SLC7A3A,SLC7A8A,SLC43A1B,SLC43A1A,SLC6A15,SLC7A3,SLC6A20,SLC43A2,SLC6A19A,SLC6A12
    Transport of inorganic cations/anions and amino acids/oligopeptides SLC26A3.1,SLC43A2B,SLC6A15,SLC43A1A,SLC7A6,SLC38A3,SLC26A6L,SLC9A7,SLC4A2B,SLC7A3A
    Transmembrane transport of small molecules SLC28A3,SLC12A1,MIPA,ABCF1,SRI,SLC9A10,CUTC,AQP1A.1,LCN2,SLC15A3
    Hemostasis ANGPT2A,Alb,KIF5A,CLU,KCNMB2,ESAMA,BRPF3,MFN1,MFN2,GATA5
    SLC-mediated transmembrane transport SLC5A9,SLC6A19B,SLC20A2,SLC2A15B,SLC22A7,SLC4A2B,SLC12A3,SLC3A2B,SLC16A7,LCN9

    Protein Function

    SLC7A11 has several biochemical functions, for example, cystine:glutamate antiporter activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SLC7A11 itself. We selected most functions SLC7A11 had, and list some proteins which have the same functions with SLC7A11. You can find most of the proteins on our site.

    Function Related Protein
    protein binding LIMD2,ATP4B,RAD54L,NDFIP1,SLC6A4,THEM5,PLN,HAGH,STAU2,MVP

    Interacting Protein

    SLC7A11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SLC7A11 here. Most of them are supplied by our site. Hope this information will be useful for your research of SLC7A11.

    CD44

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