SIRPG
-
Official Full Name
signal-regulatory protein gamma -
Overview
The protein encoded by this gene is a member of the signal-regulatory protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
SIRPG;signal-regulatory protein gamma;signal regulatory protein beta 2 , SIRPB2;bA77C3.1;CD172g;SIRP B2;SIRPgamma;CD172 antigen like family member B;CD172 antigen-like family member B;CD172g antigen;FLJ42230;RP11-77C3.2;Signal regulatory protein beta 2;Signal regulatory protein gamma;Signal-regulatory protein beta-2;SIRP beta 2;SIRP gamma;SIRP-b2;SIRP-beta-2;SIRP-gamma;SIRPB2;SIRPG_HUMAN;OTTHUMP00000029998;OTTHUMP00000029999;OTTHUMP00000030000;OTTHUMP00000185041;signal-regulatory protein beta 2;CD172 antigen-like family membe
Recombinant Proteins
- Human
- Cynomolgus
- E.coli
- HEK293
- Human Cell
- Insect cell
- Yeast
- Mammalian cells
- GST
- His
- Fc
- Non
- His&Avi
- His&Fc
Involved Pathway
SIRPG involved in several pathways and played different roles in them. We selected most pathways SIRPG participated on our site, such as Osteoclast differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRPG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | STAT1,PIK3R1,TNFSF11,TYK2,SIRPA,IFNAR2,ITGB3,CSF1R,TNFRSF1A,RAC1 |
Protein Function
SIRPG has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRPG itself. We selected most functions SIRPG had, and list some proteins which have the same functions with SIRPG. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FLCN,KIAA0141,MACF1,KLRK1,AGO3,CSTF2T,BEND7,PTK2,HSPD1,NPHS1 |
Interacting Protein
SIRPG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRPG here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRPG.
CD47
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References
- Sosale, NG; Rouhiparkouhi, T; et al. Cell rigidity and shape override CD47's "sell"-signaling in phagocytosis by hyperactivating myosin-II. BLOOD 125:542-552(2015).
- Nettleship, JE; Ren, JS; et al. Crystal structure of signal regulatory protein gamma (SIRP gamma) in complex with an antibody Fab fragment. BMC STRUCTURAL BIOLOGY 13:-(2013).
