SHMT2
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Official Full Name
serine hydroxymethyltransferase 2 (mitochondrial) -
Overview
This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants. -
Synonyms
SHMT2;serine hydroxymethyltransferase 2 (mitochondrial);SHMT;serine hydroxymethyltransferase, mitochondrial;GLYA;Glycine hydroxymethyltransferase;Serine hydroxymethyltransferase mitochondrial;Serine methylase;SHMT 2;GLY A+;serine aldolase;threonine aldolase;serine hydroxymethylase;glycine auxotroph A, human complement for hamster
Recombinant Proteins
- Human
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SHMT2-2662H | Recombinant Human SHMT2, GST-tagged | E.coli | Human | GST | C-term-300aa | |
| SHMT2-31356TH | Recombinant Human SHMT2, His-tagged | E.coli | Human | His | 376-504 a.a. |
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| SHMT2-6698Z | Recombinant Zebrafish SHMT2 | Mammalian Cells | Zebrafish | His |
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| SHMT2-927H | Recombinant Human SHMT2 Protein, His-tagged | E.coli | Human | His |
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| SHMT2-1853HCL | Recombinant Human SHMT2 293 Cell Lysate | HEK293 | Human | Non |
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| SHMT2-0224H | Recombinant Human SHMT2 Protein (S29-H504), Tag Free | E.coli | Human | Non | S29-H504 |
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| SHMT2-0225H | Recombinant Human SHMT2 Protein (S29-H504), His tagged | E.coli | Human | His | S29-H504 |
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| SHMT2-6286H | Recombinant Human SHMT2 Protein (Asn30-His504), N-His tagged | E.coli | Human | His | Asn30-His504 |
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Involved Pathway
SHMT2 involved in several pathways and played different roles in them. We selected most pathways SHMT2 participated on our site, such as Glycine, serine and threonine metabolism,Cyanoamino acid metabolism,Glyoxylate and dicarboxylate metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with SHMT2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ATP6V0C,AMDHD1,MAN2A1,ACADVL,NDUFAB1,SUCLA2,HSD17B10,ATP6V1F,GALNTL6,EHHADH |
| One carbon pool by folate | FTCD,ST20-MTHFS,MTHFD1L,MTHFD1,MTHFD2L,MTHFS,ATIC,ALDH1L2,SHMT1,TYMS |
| Glyoxylate and dicarboxylate metabolism | CS,AGXT,MDH1,GRHPR,ANI_1_2390104,HYI,DHDPSL,AMT,MCEE,GLDC |
| Cyanoamino acid metabolism | GGT1,GGT5,GGT7,GGT6,GBA3,GGT5A,GGT1A,SHMT1 |
| Carbon metabolism | PGK1,PSAT1,PDHA1B,GLUD1,ME3,PFKMA,G6PD,MTHFR,MDH1,HADHAA |
| Glycine, serine and threonine metabolism | MAOA,THA1,GCSH,AMT,ALAS1,GCSHA,SDSL,CBS,DAO.1,ALDH7A1 |
| Biosynthesis of amino acids | MAT1A,GM5506,BCAT2,ALDOCA,PGAM1B,PSPH,THA1,CBSB,GLULA,SDS |
Protein Function
SHMT2 has several biochemical functions, for example, L-allo-threonine aldolase activity,amino acid binding,chromatin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SHMT2 itself. We selected most functions SHMT2 had, and list some proteins which have the same functions with SHMT2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | GRM6,C12orf43,POLR3F,PPIC,LPXN,PEX14,TOM1,MELK,C14orf118,FABP1 |
| chromatin binding | MB21D2,EGFR,TP63,KIAA0101,ATXN7,SSBP1,ATF2,TAL1,ZGLP1,NKX2 |
| amino acid binding | PAH,DDAH1,TDO2,TPH1,OTC,TPH1B,TPH2,TPH1A,DPYS,TAT |
| identical protein binding | PNMA5,PRMT8,PLDN,TP53,HSP90AA1,ATF3,EIF2AK3,PHYKPL,MUL1A,COL18A1 |
| glycine hydroxymethyltransferase activity | SHMT1 |
| L-allo-threonine aldolase activity | THA1,SHMT1 |
| pyridoxal phosphate binding | Alb,GAD2,CTH,AGXT2,PDXDC1,TAT,AADAT,PDXDC2P,PROSC,GAD1B |
Interacting Protein
SHMT2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SHMT2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SHMT2.
ARL6IP1;CMTM5;DEGS1;EIF1B;HLA-B;BRCC3;EIF6;GNAS;IKBKE;TRMT10C;NDRG1;DDA1;UBA5;BABAM1;BRE;TNFRSF10D
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References
- Prasannan, P; Appling, DR; et al. Human mitochondrial C(1)-tetrahydrofolate synthase: Submitochondrial localization of the full-length enzyme and characterization of a short isoform. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 481:86-93(2009).
- Chen, LF; Chan, SY; et al. Distribution of folate derivatives and enzymes for synthesis of 10-formyltetrahydrofolate in cytosolic and mitochondrial fractions of pea leaves. PLANT PHYSIOLOGY 115:299-309(1997).
