Serpind1
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Official Full Name
serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -
Overview
The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. -
Synonyms
SERPIND1;serpin peptidase inhibitor, clade D (heparin cofactor), member 1;HCF2, serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1;heparin cofactor 2;D22S673;HC II;HC2;heparin cofactor II;HLS2;serpin D1;leuserpin 2
Recombinant Proteins
- Mouse
- Human
- Rat
- Rhesus macaque
- Zebrafish
- HEK293
- E.coli
- Mammalian Cell
- Human Cell
- Mouse
- Human plasma
- Mammalian cells
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
Serpind1 involved in several pathways and played different roles in them. We selected most pathways Serpind1 participated on our site, such as Complement and coagulation cascades, which may be useful for your reference. Also, other proteins which involved in the same pathway with Serpind1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Complement and coagulation cascades | C4BPA,VWF,CFI,SERPINE1,FGB,PROC,KLKB1,A2M,F10,Serpina1b |
Protein Function
Serpind1 has several biochemical functions, for example, endopeptidase inhibitor activity,heparin binding,serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Serpind1 itself. We selected most functions Serpind1 had, and list some proteins which have the same functions with Serpind1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| endopeptidase inhibitor activity | PROS1,SPINK1,SPINT2,PI3,PZP,CST3,SERPINA1A,Serpina1b,TFPI,WFDC2 |
| serine-type endopeptidase inhibitor activity | PAPLNB,WFDC6A,SERPINB7,ITIH2,MUG2,SERPINB9,WFDC2,SERPINA1A,ITIH1,COL28A1 |
| heparin binding | LPL,CCL15,RSPO3,MSTN,IMPG2,FBLN7,ADAMTS1,COMP,APOE,ADAMTS3 |
Interacting Protein
Serpind1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Serpind1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Serpind1.
p29991-pro_0000037940;p29991-pro_0000037946;p29991-pro_0000308465;q99ib8-pro_0000045599;d-mannose;IGHG1;IGHA1;TF
Resources
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References
- Kumar, A; Bhandari, A; et al. Genetic variants and evolutionary analyses of heparin cofactor II. IMMUNOBIOLOGY 219:713-728(2014).
- Charles, JF; Coury, F; et al. The collection of NFATc1-dependent transcripts in the osteoclast includes numerous genes non-essential to physiologic bone resorption. BONE 51:902-912(2012).
