RUNX2
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Official Full Name
runt-related transcription factor 2 -
Overview
This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt;DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as;a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA;both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been;associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different;protein isoforms result from the use of alternate promoters as well as alternate splicing. -
Synonyms
RUNX2;runt-related transcription factor 2;CBFA1, CCD, CCD1;AML3;PEBP2A1;PEBP2aA1;CBF-alpha-1;PEA2-alpha A;PEBP2-alpha A;oncogene AML-3;acute myeloid leukemia 3 protein;SL3-3 enhancer factor 1 alpha A subunit;osteoblast-specific transcription f
Recombinant Proteins
- Human
- Chicken
- Mouse
- Wheat Germ
- E.coli
- Mammalian Cell
- HEK293
- Non
- His
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RUNX2-28321TH | Recombinant Human RUNX2 | Wheat Germ | Human | Non | 140 amino acids |
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| RUNX2-30473TH | Recombinant Human RUNX2 | Wheat Germ | Human | Non | 100 amino acids |
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| RUNX2-48H | Recombinant Human RUNX2 protein, His-tagged | E.coli | Human | His |
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| RUNX2-5704C | Recombinant Chicken RUNX2 | Mammalian Cell | Chicken | His |
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| Runx2-5723M | Recombinant Mouse Runx2 protein, His-tagged | E.coli | Mouse | His | Ser125~Ala352 |
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| RUNX2-2107HCL | Recombinant Human RUNX2 293 Cell Lysate | HEK293 | Human | Non |
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| RUNX2-2108HCL | Recombinant Human RUNX2 293 Cell Lysate | HEK293 | Human | Non |
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| RUNX2-1163HFL | Recombinant Full Length Human RUNX2 Protein, C-His-tagged | E.coli | Human | His | Full L. |
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| RUNX2-6644H | Recombinant Human RUNX2 Protein | E.coli | Human | Non |
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| RUNX2-6645H | Recombinant Human RUNX2 Protein (Val219-Val404), N-His tagged | E.coli | Human | His | Val219-Val404 |
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Involved Pathway
RUNX2 involved in several pathways and played different roles in them. We selected most pathways RUNX2 participated on our site, such as Transcriptional misregulation in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with RUNX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | BCL2A1A,RXRB,Itgam&Itgb2,REL,CCNT2,RELA,NFKBIZ,SUPT3H,PLAT,HOXA9 |
Protein Function
RUNX2 has several biochemical functions, for example, ATP binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,RNA polymerase II core promoter sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RUNX2 itself. We selected most functions RUNX2 had, and list some proteins which have the same functions with RUNX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| repressing transcription factor binding | HDAC9,SRI,ARNTL,MAGEA2B,RELA,NOC2L,HMGB1,MYC,DDX20,MAGEA2 |
| chromatin binding | HOXC13,ACTL6A,ANKRD2,NR5A1A,FEZF2,NOC2L,CUX1,SKI,GABPA,PRMT6 |
| bHLH transcription factor binding | SIRT1,TCF21,IKZF4,HAND1,ASCL1,USF2,MAP3K10,TCF3A,TCF3B,BHLHE40 |
| histone deacetylase binding | NR2E1,SIX3,TCF21,NIPBL,HIC1,RAD9,KAT2B,KPNA2,HIST1H1B,BRMS1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | PAX5,WT1,HMGA2,TCF21,MEF2A,GATA1,NR2E1,NKX2-8,MEIS1,NFATC2 |
| protein domain specific binding | ANGEL1,SCAF1,CEP68,HIST2H4,UNC13A,ST13,MED12,TWIST2,ABCC2,HAND2 |
| ATP binding | DHX9,SBK3,SETX,ERBB4,OAS3,ZAP70,ATM,HSP90AA1.1,RAD54B,PFKFB4 |
| transcription factor activity, sequence-specific DNA binding | SIX1B,LHX8A,HOXC4A,ZNF205,KLF3,FOXE1,KLF11,ZNF501,NFIL3-5,ZIC1 |
| RNA polymerase II core promoter sequence-specific DNA binding | STAT5A,SPI1,TFAP2A,EP300,SFPI1,ZFPM1,TRP53,STAT6,EGR1,GBX2 |
Interacting Protein
RUNX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RUNX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RUNX2.
PIN1;TP73;SMAD6;SMAD5;SMURF1;MYC
RUNX2 Related Signal Pathway
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References
- Li, YJ; El Mozen, LA; et al. Transforming growth factor beta 3 involved in the pathogenesis of synovial chondromatosis of temporomandibular joint. SCIENTIFIC REPORTS 5:-(2015).
- Xu, LL; Liu, Y; et al. U0126 promotes osteogenesis of rat bone-marrow-derived mesenchymal stem cells by activating BMP/Smad signaling pathway. CELL AND TISSUE RESEARCH 359:537-545(2015).
