RPN1
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Official Full Name
ribophorin I -
Overview
This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. -
Synonyms
RPN1;ribophorin I;dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1;oligosaccharyltransferase 1 homolog (S. cerevisiae);OST1;D6Wsu137e;Dolichyl diphosphooligosaccharide protein glycosyltransferase 67 kDa subunit precursor;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit;EC 2.4.1.119;RBPH1;Ribophorin-1;RPN-I;RPN1_HUMAN;OTTHUMP00000216245;OTTHUMP00000216575;oligosaccharyltransferase 1 homolog;dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit;dolichyl-dip
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- His
- GST
- Non
- DDK
- Myc
- Flag
- Avi
- Fc
Involved Pathway
RPN1 involved in several pathways and played different roles in them. We selected most pathways RPN1 participated on our site, such as N-Glycan biosynthesis,Metabolic pathways,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPN1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein processing in endoplasmic reticulum | VIMP,DNAJA2,MBTPS1,HSPA1L,RAD23A,HSP90B1,PKZ,VCP,DNAJC5AA,SAR1B |
| N-Glycan biosynthesis | GANAB,ALG13,B4GALT3,DAD1,FUT8A,DOLK,MGAT3,ALG12,ST6GAL2A,DPM1 |
| Metabolic pathways | ST6GALNAC5,UGP2B,AGL,ALPI.2,GLULB,ZNRD1,PON3,PLA2G6,SAT2B,AKR1C4 |
Protein Function
RPN1 has several biochemical functions, for example, contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPN1 itself. We selected most functions RPN1 had, and list some proteins which have the same functions with RPN1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | BEX2,CAPG,TLE2,MPHOSPH6,TPD52L3,KCTD5,SAFB2,GDNF,UBE2L3,HSD17B8 |
| contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity | RPN2,STT3A,OSTC,DDOST,TUSC3,DAD1 |
| poly(A) RNA binding | UBE2N,FXR1,SYF2,PPIA,PUS1,FKBP3,ZFP346,MAP4,LGALS3,MKI67IP |
Interacting Protein
RPN1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPN1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPN1.
SGTA;UBQLN1;UBQLN1;VCAM1;ESR1;env;HLA-B;GABARAPL2;ARF6
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References
- Spirig, U; Bodmer, D; et al. The 3.4-kDa Ost4 protein is required for the assembly of two distinct oligosaccharyltransferase complexes in yeast. GLYCOBIOLOGY 15:1396-1406(2005).
- Farah, CA; Liazoghli, D; et al. Interaction of microtubule-associated protein-2 and p63 - A new link between microtubules and rough endoplasmic reticulum membranes in neurons. JOURNAL OF BIOLOGICAL CHEMISTRY 280:9439-9449(2005).
