RING1
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Official Full Name
ring finger protein 1 -
Overview
This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a;zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional;repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the;polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It;interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region,;where it is contiguous with the RING finger genes FABGL and HKE4. -
Synonyms
RING1;ring finger protein 1;E3 ubiquitin-protein ligase RING1;RNF1;polycomb complex protein RING1;really interesting new gene 1 protein;RING1A
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
RING1 involved in several pathways and played different roles in them. We selected most pathways RING1 participated on our site, such as Cellular Senescence,Cellular responses to stress,Delta-Notch Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RING1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Oxidative Stress Induced Senescence | EED,CBX4,SUZ12A,KDM6B,MINK1,PHC3,SUZ12,PHC1,CBX6A,BMI1B |
| SUMO E3 ligases SUMOylate target proteins | CBX4,SMC5,SMC6,NSMCE4A,NSMCE1,PHC2,PHC1,NSMCE2,CBX8,PHC3 |
| Delta-Notch Signaling Pathway | HEY1,SMAD3B,JAG1,ASCL1A,ADAM10A,NOV,TUBB3,MAGEA1,CNTN1,HES6 |
| Metabolism of proteins | DHPS,TOMM6,RNF2,KCNA3,DNAJC24,SMC5,MGAT4B,MFGE8,SLC34A2A,ADAMTSL1 |
| Cellular responses to stress | CBX8B,CDKN2D,AMBRA1,BAG3,RNF2,KIAA1967,H1F0,GABARAPL2,RRAGA,EP400 |
| Cellular Senescence | CDK6,CDK4,AGO1,ASF1A,CBX8B,MINK1,BMI1B,HIST3H2BB,KDM6B,KAT5 |
| SUMOylation | UBA2,SMC5,NSMCE1,PHC3,SENP5,NSMCE2,SENP1,SAE1,PHC1,RNF2 |
| Post-translational protein modification | MAN1B1,MPDU1A,ADAMTS8,TRAPPC4,UBA2,C8orf84,MUC20,LMAN2L,EIF5A,A4GNT |
Protein Function
RING1 has several biochemical functions, for example, chromatin binding,ligase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RING1 itself. We selected most functions RING1 had, and list some proteins which have the same functions with RING1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ubiquitin-protein transferase activator activity | CBX8,UBE2L3,FBXW7,AUP1 |
| chromatin binding | ANKRD17,FEZF2,TCF7,ARID3A,NCOA5,MORF4L1,GATA6,HINFP,CREB3L1,SMAD4 |
| protein binding | NOC4L,MSH2,ARIH2,ZNF259,GPKOW,FANCL,B2M,TMSB10,PIM2,MMP14 |
| zinc ion binding | RNF182,SYVN1,TRIM40,NUP153,PHF19,ZZZ3,MYNN,ZNF385C,LNX2B,PHF11 |
| ligase activity | STUB1,TRIM50,SIAH1,TRIM39,CBX4,ACSL1,MKRN1,NEDD4L,RNF139,TRIM41 |
Interacting Protein
RING1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RING1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RING1.
BMI1;CBX8
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References
- Pemberton, H; Anderton, E; et al. Genome-wide co-localization of Polycomb orthologs and their effects on gene expression in human fibroblasts. GENOME BIOLOGY 15:-(2014).
- Endoh, M; Endo, TA; et al. Polycomb group proteins Ring1A/B are functionally linked to the core transcriptional regulatory circuitry to maintain ES cell identity. DEVELOPMENT 135:1513-1524(2008).
