RGS4
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Official Full Name
regulator of G-protein signaling 4 -
Overview
Regulators of G protein signaling (RGS) are a family of about 40 proteins that determine the signaling amplitude and duration of G protein-coupled receptor signaling via modulation of the GTPase activity of G proteins. Each RGS has a distinct structure, e -
Synonyms
RGS4;regulator of G-protein signaling 4;regulator of G protein signalling 4 , schizophrenia disorder 9 , SCZD9;schizophrenia disorder 9;RGP4;SCZD9;MGC2124;MGC60244;DKFZp761F1924
Recombinant Proteins
- Mouse
- Human
- Rat
- Chicken
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- Myc&DDK
- Flag
- His&Fc&Avi
- GST
Involved Pathway
RGS4 involved in several pathways and played different roles in them. We selected most pathways RGS4 participated on our site, such as Calcium Regulation in the Cardiac Cell,G alpha (i) signalling events,G alpha (z) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | SSTR5,ABHD6B,PIK3R6,ADRA2B,PMCH,CHRM1,NET1,ITSN1,OR7D2,TAS2R16 |
| Calcium Regulation in the Cardiac Cell | CX34.4,RGS18,GNG13B,RGS5B,CCDC102A,GJB3,KCNJ3,ADRA1B,ADRA1D,CX55.5 |
| G alpha (i) signalling events | TAS2R16,CCR7,CCR3,PTGDR2,TAS2R13,OPN1LW2,CXCR7B,S1PR3,RGS12,APLNR |
| Signal Transduction | HHAT,OXER1,AES,GRB10A,ARHGAP19,PENK,GPR65,OPN4.1,RBBP5,KAL1A |
| Signaling by GPCR | GPR18,PPY,PTH,VIP,RGS18,TRH,GPR37L1,OR52J3,RGS7,GPBAR1 |
| G alpha (z) signalling events | ADRA2B,ADRA2C,RGS17,ADRA2A,RGS19,RGS20 |
| Myometrial Relaxation and Contraction Pathways | CNN2,GPR182,ACTA1,RGS5,RGS17,CORIN,GABPB1,RGS14,RGS11,RXFP2 |
Protein Function
RGS4 has several biochemical functions, for example, G-protein alpha-subunit binding,GTPase activator activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS4 itself. We selected most functions RGS4 had, and list some proteins which have the same functions with RGS4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| G-protein alpha-subunit binding | ARHGEF11,LPAR1,DRD1,AGTR1A,NUCB1,PPP5C,RGS19,ADRB2,RIC8A,RIC8 |
| GTPase activator activity | RGS17,FAM13B1,RANGAP1B,MURC,ELMOD2,TBC1D3B,RGS10,GRTP1A,RGS5A,GIT2A |
| calmodulin binding | NETO2,PCP4,PCDP1,TRPV6,KCNN1,MAPKAPK5,MYH11,GAP43,TRPV5,ADCY3 |
Interacting Protein
RGS4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS4 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS4.
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References
- Shirley, MD; Tang, H; et al. Sturge-Weber Syndrome and Port-Wine Stains Caused by Somatic Mutation in GNAQ. NEW ENGLAND JOURNAL OF MEDICINE 368:1971-1979(2013).
