RBBP6
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Official Full Name
retinoblastoma binding protein 6 -
Overview
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. -
Synonyms
RBBP6;retinoblastoma binding protein 6;E3 ubiquitin-protein ligase RBBP6;P2P R;PACT;proliferation potential related protein;SNAMA;protein P2P-R;RB-binding Q-protein 1;retinoblastoma-binding Q protein 1;proliferation potential-related protein;p5
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| RBBP6-2200H | Recombinant Human RBBP6, GST-tagged | E.coli | Human | GST | 1-118aa | |
| RBBP6-1160Z | Recombinant Zebrafish RBBP6 | Mammalian Cells | Zebrafish | His |
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| RBBP6-23H | Recombinant Human RBBP6 protein, GST-tagged | Wheat Germ | Human | GST | 1 a.a. - 118 a.a. |
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| RBBP6-7794Z | Recombinant Zebrafish RBBP6 | Mammalian Cells | Zebrafish | His |
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| RBBP6-1480HCL | Recombinant Human RBBP6 cell lysate | Human | Non |
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| RBBP6-2201H | Recombinant Human RBBP6 protein(Thr1151-Gly1260), His-tagged | E.coli | Human | His | Thr1151-Gly1260 |
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Involved Pathway
RBBP6 involved in several pathways and played different roles in them. We selected most pathways RBBP6 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with RBBP6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
RBBP6 has several biochemical functions, for example, ligase activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RBBP6 itself. We selected most functions RBBP6 had, and list some proteins which have the same functions with RBBP6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ligase activity | RNF217,TRIM21,UBOX5,PRPF19,BIRC3,RNF185,TRAF6,RNF126,TRIM33,HECW2 |
| zinc ion binding | SYTL4,LHX1B,PMPCB,Shh,XIAP,ADAM25,TRIM38,DPF2,RARAB,DZIP3 |
| ubiquitin-protein transferase activity | CNOT4,FBXO30A,TRIM27,UBE3A,HACE1,MALT1,UBE3C,TRIM62,RNF125,SHPRH |
| poly(A) RNA binding | DDX39B,SLC25A5,PSIP1,LGALS1,RPUSD3,RBM8A,RRP8,YWHAE,ADAR,KHDRBS3 |
| protein binding | CREB3L3,CCNE1,FAM114A1,TEN1,SPTA1,TNNI2,TRPC1,MAGOH,UBL5,AKT1 |
| ubiquitin protein ligase activity | MED21,RABGEF1,PDZRN3,HERC3,PELI1,PDZD4,G2E3,ANKIB1,TRIM63,ARIH2 |
Interacting Protein
RBBP6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RBBP6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RBBP6.
SRSF7;TFCP2;POLR2D;KHDRBS3;PIAS1;ZFYVE9;HP;PLG;APOH;ASGR1;TPT1;GLUL;CAPZA2;VAV2;GRB2;UBE2I;SMN1;pgi
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