RARG

  • Official Full Name

    retinoic acid receptor, gamma

  • Overview

    This gene encodes a retinoic acid receptor that belongs to the nuclear hormone receptor family. Retinoic acid receptors (RARs) act as ligand-dependent transcriptional regulators. When bound to ligands, RARs activate transcription by binding as heterodimers to the retinoic acid response elements (RARE) found in the promoter regions of the target genes. In their unbound form, RARs repress transcription of their target genes. RARs are involved in various biological processes, including limb bud development, skeletal growth, and matrix homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

  • Synonyms

    RARG;retinoic acid receptor, gamma;retinoic acid receptor gamma;NR1B3;RARC;Nuclear receptor subfamily 1 group B member 3;RAR gamma;Retinoic acid receptor gamma 1;Retinoic acid receptor gamma 2;Retinoic acid receptor gamma polypeptide;RAR-gamma;OTTHUMP00000045736;OTTHUMP00000241950;OTTHUMP00000241951;OTTHUMP00000241952;retinoic acid nuclear receptor gamma variant 1;retinoic acid nuclear receptor gamma variant 2

Recombinant Proteins

  • Human
  • Mouse
  • E.coli
  • Sf9 Insect Cell
  • Insect Cell
  • Mammalian Cell
  • HEK293
  • HEK293T
  • GST
  • Non
  • His
  • Myc&DDK
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
RARG-2184H Recombinant Human RARG, GST-tagged E.coli Human GST N-term-300aa
RARG-1135H Active Recombinant Human Retinoic Acid Receptor, Gamma Sf9 Insect Cell Human Non
RARG-2512H Active Recombinant Human Retinoic Acid Receptor, Gamma, His-tagged Insect Cell Human His
RARG-1137H Recombinant Human RARG, Ligand Binding Domain Sf9 Insect Cell Human Non
RARG-1138H Recombinant Human RARG, Ligand Binding Domain, GST-tagged Sf9 Insect Cell Human GST
RARG-13934M Recombinant Mouse RARG Protein Mammalian Cell Mouse His
RARG-31055TH Recombinant Human RARG, His-tagged Human His 150-417 a.a.
RARG-31057TH Recombinant Human RARG Human Non 150-417 a.a.
RARG-31059TH Recombinant Human RARG, GST-tagged Human GST Full L.
RARG-31060TH Recombinant Human RARG, His-tagged Human His Full L.
RARG-2512HCL Recombinant Human RARG 293 Cell Lysate HEK293 Human Non
RARG-1130H Recombinant Human RARG-LBD Protein, His-tagged E.coli Human His 154-415
RARG-3766H Recombinant Human RARG Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
Rarg-5381M Recombinant Mouse Rarg Protein, Myc/DDK-tagged HEK293T Mouse Myc&DDK
RARG-7425M Recombinant Mouse RARG Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
RARG-7425M-B Recombinant Mouse RARG Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    RARG involved in several pathways and played different roles in them. We selected most pathways RARG participated on our site, such as Gene Expression,Generic Transcription Pathway,Nuclear Receptor transcription pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nuclear receptors in lipid metabolism and toxicity NR1I2,NR1I3,RARGB,CYP24A1,RARGA,VDRB,CYP27B1,CYP26A1,ABCC2
    Nuclear Receptor transcription pathway NR2F6,NRBF2,ESR2A,NR2F1B,NR4A2B,RORAA,RARGA,ESR2B,NR2E3,NR1H3
    Signal Transduction AXL,THBS3B,CDC42EP2,DNAL4A,PTHRP2,METAP2A,MDK,RLN1,AKAP13,PENK
    Gene Expression ZNF23,ZNF606,FKBP6,HNRNPH1L,ZMAT5,TBX5,ZNF263,RRP8,ZNF493,APEH
    Generic Transcription Pathway ZNF596,ZKSCAN1,ZNF773,ZNF184,ZNF750,ZNF740,NRBF2,MED25,NKX2,ZNF785
    Vitamin A and carotenoid metabolism RDH10,RDH12,DHRS3,BCO2,CRABP2,CRABP1,RBP7
    Nuclear Receptors NR2F2,NR0B1,NR1D2B,RARGB,NR2F1,NR2F1A,NR2C2,VDRB,NR5A1,NR1I2
    Signaling by Retinoic Acid CRABP1B,RDH7,DHRS9,FABP11B,RDH14,CRABP1A,RDH14B,SDR16C5,RDH13,DHRS3A

    Protein Function

    RARG has several biochemical functions, for example, DNA binding,RNA polymerase II regulatory region sequence-specific DNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARG itself. We selected most functions RARG had, and list some proteins which have the same functions with RARG. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II regulatory region sequence-specific DNA binding CREB3,BCL6A,ZNF79,JARID2,ASCL3,ARID3A,MEF2A,TBX5,HOXD8,PHOX2A
    retinoid X receptor binding NR1H2,PPARG,NR4A2,VDR,NR1H4,NCOR1,HMGA1,MED25,NSD1,NCOA1
    DNA binding RAD52,FAM170A,LIN54,EVX2,ZNF559-ZNF177,JRKL,DHX36,AHDC1,HOXC12A,NKX2.1
    steroid hormone receptor activity ESR2B,NR2C1,PAQR7B,RXRBA,PPARD,RXRB,NR2C2,PPARG,RARB,ESRRB
    retinoic acid receptor activity RARAB,RARGB,RARB,RXRA,NR1D4B,RARAA,ESRRG,RARGA,RARA
    protein binding EMP1,PTPRM,TBC1D14,KRT40,TTPA,PHF10,CREB3,KCNMA1,SLC8A1,UBA7
    zinc ion binding GTF2H2C_2,VDRB,TXNDC17,ALKBH8,ZNRF2,PHF23A,SIAH1,Car8,ADAM20,ZFML
    transcription factor activity, sequence-specific DNA binding CREB3L3A,ARNT,GCM2,MAFBA,ZSCAN16,SOX3,FOXC1,ZNF239,NR1I3,WT1

    Interacting Protein

    RARG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARG here. Most of them are supplied by our site. Hope this information will be useful for your research of RARG.

    SORBS3;ZNF423;OIP5;MRPL12;IL24;LSR;RHPN2;ACY3;ZNF576;SPHK1;Sorbs3;MTMR6;FOXC1;myc_human_gene;tff1_human_gene;GREB1;ESR1;RARA

    Resources

    Research Area

    Transcription Regulators in VSMC
    Multiple Sclerosis and Myelin Related Molecules

    References

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