RAPGEF3
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Official Full Name
Rap guanine nucleotide exchange factor (GEF) 3 -
Overview
EPAC1 and EPAC2 (exchange proteins activated by cyclic AMP) are guanine nucleotide exchange factors (GEFs) that catalyze the exchange of GDP for GTP, activating Rap1 and Rap2 small GTPases. Rap activation by EPAC is cAMP-dependent and mediates cAMP signal -
Synonyms
RAPGEF3;Rap guanine nucleotide exchange factor (GEF) 3;rap guanine nucleotide exchange factor 3;bcm910;cAMP GEFI;EPAC;exchange protein directly activated by cAMP 1;EPAC 1;9330170P05Rik;exchange fact
Recombinant Proteins
- Human
- Rat
- Mouse
- E.coli
- Wheat Germ
- HEK293
- Mammalian Cells
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
- Flag
Involved Pathway
RAPGEF3 involved in several pathways and played different roles in them. We selected most pathways RAPGEF3 participated on our site, such as Adaptive Immune System,Adrenergic signaling in cardiomyocytes,Hemostasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAPGEF3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hemostasis | GATA6,PIK3R6,SLC16A1,APOBB.1,KIF18A,KLC3,CABLES2,MAFF,CLU,CXADR |
| Immune System | ATG7,SPSB2,CTSC,TRAF7,KIF11,BTR06,LTN1,LILRA1,TREML4,PIK3AP1 |
| Adrenergic signaling in cardiomyocytes | TNNC1,MAPK14A,ATP1B2B,PLCB3,ADCY1,PPP2R2C,PIK3CG,ATP1A3,PPP2R2D,ADCY9 |
| Integrated Pancreatic Cancer Pathway | CD82,GPRC5A,RB1CC1,AGA,IL11,WRN,FST,CASP12,TFF1,FKBP1B |
| Adaptive Immune System | LAIR2,LRR1,CD207,MGC174152,CSK,IGHM,AP2A2,SPSB4,DNM2,SIGLEC12 |
| Integrin alphaIIb beta3 signaling | ITGB3A,RAPGEF4,FN1B,LOC100514666 |
| Integration of energy metabolism | GNB5A,MARCKSA,KCNS3,GNG13B,KCNB1,ARL2,KCNC2,GNG13A,AKAP5,RAPGEF4 |
Protein Function
RAPGEF3 has several biochemical functions, for example, Rap guanyl-nucleotide exchange factor activity,cAMP binding,guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAPGEF3 itself. We selected most functions RAPGEF3 had, and list some proteins which have the same functions with RAPGEF3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| guanyl-nucleotide exchange factor activity | FGD6,GAPVD1,ARHGEF19,DENND5B,ARHGEF1B,DOCK7,DOCK6,ANKRD27,ARHGEF18,FGD5 |
| cAMP binding | RAPGEF4,PRKAR1A,CNGA2,CNGA4,PDE2A,HCN4,PDE3A,BVES,HCN2,PDE4B |
| Rap guanyl-nucleotide exchange factor activity | RAPGEF5,RAP1A |
| protein binding | PUM2,AGTRAP,PIK3CB,LC3,FGFR1OP2,MUC5B,MARCH10,SOX6,HIST1H2AK,ZNF266 |
| protein domain specific binding | DVL2,CALM2,NEFL,FOXH1,ATP1A1,ACSL3,TBL1X,RAP2B,TRIM11,TNNI3 |
Interacting Protein
RAPGEF3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAPGEF3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAPGEF3.
PDE3B;3',5'-cyclic amp;7-ch-c_amp;mant-gdp;RAP1B;PIK3R6
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References
- Fang, ZQ; Zang, WD; et al. Gene expression profile and enrichment pathways in different stages of bladder cancer. GENETICS AND MOLECULAR RESEARCH 12:1479-1489(2013).
- Vadnais, ML; Aghajanian, HK; et al. Signaling in Sperm: Toward a Molecular Understanding of the Acquisition of Sperm Motility in the Mouse Epididymis. BIOLOGY OF REPRODUCTION 89:-(2013).
