RAP1B
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Official Full Name
RAP1B, member of RAS oncogene family -
Overview
Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCR), death domain associated receptors (DD-R) and ion channels (1 -
Synonyms
RAP1B;RAP1B, member of RAS oncogene family;ras-related protein Rap-1b;DKFZp586H0723;K REV;RAL1B;RAS-related protein RAP1B;small GTP binding protein;GTP-binding protein smg p21B;Ras family small GTP binding protein RAP1B;K-REV;FLJ18601
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Rat
- Cynomolgus
- Zebrafish
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Avi
- Fc
- DDK
- Myc
Involved Pathway
RAP1B involved in several pathways and played different roles in them. We selected most pathways RAP1B participated on our site, such as MAPK signaling pathway,Ras signaling pathway,Rap signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAP1B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pancreatic secretion | SCTR,RAP1A,PLA2G2E,PLA2G12B,PLA2G3,RHOA,LOC780933,ATP1A2,PRSS2,ATP1A3 |
| Rap signaling pathway | Kitl,SRC,GRIN2A,FGFR1,FGF14,FPR1,ITGA2B,MAGI1,FGF12,FGF18 |
| Ras signaling pathway | PAK2,PAK1,VEGFA,FGFR3,Kitl,GRB2,FGFR2,GNG10,PDGFRA,PRKCB |
| MAPK signaling pathway | PRKACAA,MAPK6,MAP3K4,FGF1A,FGF14,PPM1BB,GNG12,MAPKAPK3,DDIT3,FGFR1A |
| Platelet activation | FGA,PIK3CD,VWF,FGG,PLA2G4F,FGB,MYLK3,GNAQ,MYLK4,PIK3R2 |
| Long-term potentiation | PPP1R1A,EP300,CALML5,GRIN2D,BRAF,RPS6KA6,PLCB4,MAPK3,KRAS,CAMK4 |
| Focal adhesion | COL4A2,PARVG,RHOAD,RAC2,MAPK8,MYLK,ARHGAP35,GSK3B,SHC1,RAP1AA |
| Chemokine signaling pathway | PARD3,CXCL5,GNGT2,ARRB2,CCL4,PIK3CB,GNGT1,PIK3CG,GM13304,RELA |
| Neurotrophin signaling pathway | MAPK7,MAPK9,MAP2K1,MAP2K7,MAPK10,MAP3K3,PLCG1,BDNF,KRAS,SH2B3 |
Protein Function
RAP1B has several biochemical functions, for example, GDP binding,GTP binding,GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAP1B itself. We selected most functions RAP1B had, and list some proteins which have the same functions with RAP1B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GDP binding | SRP54A,EIF2B1,RAB5C,RAB17,RAB7,KRAS,MIEF1,SEPT12,SRP54,RAB22A |
| protein complex binding | ULK1,ITGB1BP1,MAPK8IP2,C8B,RPH3A,HADHA,IGBP1,SLC9A3R1,KIF11,KAT2B |
| GTP binding | ARL5B,GUCY1A3,DNAJC27,TUBA8,ARL2,SEPT10,HRASA,URGCP,MXB,ARF4B |
| protein binding | DRD1A,KCNE1L,SUV39H2,ZBTB49,KATNAL1,PHLPP1,RAB9A,TPSB2,GTF2E2,ZHX3 |
| GTPase activity | RAB34A,GNA11B,RRAS2,GTPBP10,RHOU,GTPBP4,TUBA8L3,RAB3D,RAB1B,RRAGCB |
Interacting Protein
RAP1B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAP1B here. Most of them are supplied by our site. Hope this information will be useful for your research of RAP1B.
RALGDS;RASSF5;VCAM1;UBC;RAP1GAP;RAPGEF3;MCC;PAK2;MAP3K14;SMURF2;RGL2
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References
- Subramanian, H; Zahedi, RP; et al. Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 11:1574-1582(2013).
- Sayyah, J; Bartakova, A; et al. The Ras-related Protein, Rap1A, Mediates Thrombin-stimulated, Integrin-dependent Glioblastoma Cell Proliferation and Tumor Growth. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17689-17698(2014).
