PTPRC
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Official Full Name
protein tyrosine phosphatase, receptor type, C -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] -
Synonyms
PTPRC;protein tyrosine phosphatase, receptor type, C;LCA;LY5;B220;CD45;L-CA;T200;CD45R;GP180;receptor-type tyrosine-protein phosphatase C;CD45 antigen;T200 glycoprotein;T200 leukocyte common antigen;protein tyrosine phosphatase, receptor type, c polypeptide
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Golden hamster
- Human Cells
- Sf9 Cells
- Insect Cells
- Mammalian Cells
- HEK293
- C-hFc
- E.coli
- CHO
- Yeast
- Fc
- His
- Non
- His&GST
- GST
- His&Flag
- StrepII
- Myc&DDK
- His&S
- His&Avi
- Flag
- His&SUMO
- His&Fc&Avi
- His&Strep II
Involved Pathway
PTPRC involved in several pathways and played different roles in them. We selected most pathways PTPRC participated on our site, such as Cell adhesion molecules (CAMs),T cell receptor signaling pathway,Fc gamma R-mediated phagocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| nodeficiency | CD8B1,BLNK,ORAI1,LCK,ZAP70,AICDA,RFX5,CD3D,UNG,AIRE |
| Primary i | CD8A,Cd79a,TAP1, Cd79b,RAG1,RFXANK,RFX5,CD19,AICDA,CD79A |
| Cell adhesion molecules (CAMs) | ITGB7,Siglec1,ITGB1B.2,CLDN22,JAM3,ITGA6,CLDNB,CDH3,MPZL1L,VCAM1 |
| T cell receptor signaling pathway | PTPN6,NCK1,SHB,PPP3CC,MAP3K14,PIK3R2,PAK1,OXSR1A,PDCD1,GRB2 |
| Fc gamma R-mediated phagocytosis | PIK3CG,RPS6KB2,HCK,RPS6KB1,MARCKS,cgr2b,MAPK3,FCGR1A,WASF1,NCF1 |
Protein Function
PTPRC has several biochemical functions, for example, protein binding,protein kinase binding,protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRC itself. We selected most functions PTPRC had, and list some proteins which have the same functions with PTPRC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAGEA1,UCKL1,SEPSECS,ZNF346,UBAC1,NUDCD2,KIAA1267,BMP7,GSG2,PLK3 |
| protein kinase binding | BCL10,CDC25B,NGFRAP1,CCNL1,ADRA2A,MAPK4,SMAD3,HIF1A,PTPN6,TRIM22 |
| protein tyrosine phosphatase activity | MTMR4,MTMR1,DUSP23A,MTMR2,PTPN22,PTPN3,PTPN7,DUSP21,CDKN3,PTPN4B |
| transmembrane receptor protein tyrosine phosphatase activity | PTPN6,PTPRE,PTPRF,PTPRA,PTPRG,PTPRO,PTPRM,PTPRR,PTPRN2,EVLA |
Interacting Protein
PTPRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRC here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRC.
LCK;CSK;CTNNB1;LGALS1;ITGAL;PDPK1;EGFR;ERBB2
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References
- Lv, W; Duan, QL; et al. Expression of B-cell-associated genes in peripheral blood mononuclear cells of patients with symptomatic pulmonary embolism. MOLECULAR MEDICINE REPORTS 11:2299-2305(2015).
- Aspinall-O'Dea, M; Pierce, A; et al. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. NATURE PROTOCOLS 10:149-168(2015).
