PTHLH
-
Official Full Name
parathyroid hormone-like hormone -
Overview
The protein encoded by this gene is a member of the parathyroid hormone family. This hormone regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. This hormone is involved in lactation possibly by regulating the mobilization and transfer of calcium to the milk. The receptor of this hormone, PTHR1, is responsible for most cases of humoral hypercalcemia of malignancy. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. There is also evidence for alternative translation initiation from non-AUG (CUG and GUG) start sites, in-frame and downstream of the initiator AUG codon, to give rise to nuclear forms of this hormone. -
Synonyms
PTHLH;HHM;PLP;BDE2;PTHR;PTHRP;MGC14611;parathyroid hormone-like hormone;Parathyroid hormone-related protein
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Cattle
- Dog
- Mouse
- E.coli
- HEK293
- Mammalian Cells
- Protein Conjugation
- Non
- His
- His&S
- GST
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PTHLH involved in several pathways and played different roles in them. We selected most pathways PTHLH participated on our site, such as Class B/2 (Secretin family receptors),Endochondral Ossification,G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTHLH were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endochondral Ossification | PTHLHA,IFT88,CTSL2,ADAMTS4,MMP13,SERPINH1,ADAMTS1,MGP,NKX3.2,CST5 |
| Signal Transduction | GPR132B,ADH8A,SOX13,CDH5,ROR1,FAM13B1,RHOT1A,RARG,RGS21,RNF41 |
| Signaling by GPCR | RGS20,GPR4,RGS18,GAL,CCBP2,TAS2R16,RCA2.1,ARHGEF18,RGS21,GPR39 |
| Class B/2 (Secretin family receptors) | RAMP3,ADCYAP1B,CD97,RAMP1,GNB5B,GHRH,EMR4,FZD10,CALCRL,ADM |
| Signaling events mediated by the Hedgehog family | LRPAP1 |
| GPCR downstream signaling | OXER1,DGKB,ARHGEF16,PTGDR2,LPAR5A,DRD4,OPN1MW,RXFP2B,PNOC,APPB |
| GPCR ligand binding | CHRM1,PNOC,ADRA2B,ADCYAP1,PTH2,CRH,CNR1,TAC3,RLN3A,RAMP3 |
| G alpha (s) signalling events | RAMP1,ADCYAP1,CRHR1,PTHRP2,ADORA2B,CALCA,VIP,ADM2A,ADRB3,ADM2 |
Protein Function
PTHLH has several biochemical functions, for example, hormone activity,peptide hormone receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTHLH itself. We selected most functions PTHLH had, and list some proteins which have the same functions with PTHLH. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone activity | STC2,PYY,SST6,LRSAM1,INHBE,SMTLA,INSL5,ADCYAP1A,URP2,GAST |
| peptide hormone receptor binding | JAK2,PTHLHA,NPPC,NPPA,FYN,PTPN11,RUNDC3A,LEP,ADCYAP1,PTH |
Interacting Protein
PTHLH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTHLH here. Most of them are supplied by our site. Hope this information will be useful for your research of PTHLH.
PLK1
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References
- Dale, MD; Mortimer, EM; et al. Bone-Remodeling Transcript Levels Are Independent of Perching in End-of-Lay White Leghorn Chickens. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 16:2663-2677(2015).
- Galloway, TS; Fletcher, T; et al. PFOA and PFOS are associated with reduced expression of the parathyroid hormone 2 receptor (PTH2R) gene in women. CHEMOSPHERE 120:555-562(2015).
