PRKRA
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Official Full Name
protein kinase, interferon-inducible double stranded RNA dependent activator -
Overview
This gene encodes a protein kinase activated by double-stranded RNA which mediates the effects of interferon in response to viral infection. Mutations in this gene have been associated with dystonia. Alternative splicing results in multiple transcript variants. -
Synonyms
PRKRA;protein kinase, interferon-inducible double stranded RNA dependent activator;interferon-inducible double stranded RNA-dependent protein kinase activator A;DYT16;HSD14;PACT;protein activator of the interferon induced protein kinase;RAX;PKR-as
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Zebrafish
- Bovine
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- Flag
- Avi
- Fc
- Myc
- DDK
Involved Pathway
PRKRA involved in several pathways and played different roles in them. We selected most pathways PRKRA participated on our site, such as Aflatoxin B1 metabolism,Aflatoxin activation and detoxification,Biological oxidations, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRKRA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Aflatoxin B1 metabolism | CYP2A13,CYP3A4,CYP1A2,FAM84B |
| Metabolism of xenobiotics by cytochrome P450 | CYP2S1,ADH2-2,GSTK1,AKR1C4,CYP2F1,ADH2-1,AKR1C2 |
| Aflatoxin activation and detoxification | CYP3A4,ACY3,CYP3A5,DPEP2,CYP1A2,CYP2A13,ACY3.2,CYP3C1,ACY3.1,DPEP1 |
| metapathway biotransformation | SULT4A1,CYP20A1,NAA20,NAT8B,NAA40,NAT9,GAL3ST4,NAT14,RHBDL1,NAA50 |
| Biological oxidations | CYP26A1,CYP2K22,CYP11B2,CYP2AD2,COMT,CYP2AD6,CYP3A7,GSTO2,SLC35D1A,UGT1B1 |
| Metabolism | SLC25A27,GLYATL2,CYP27B1,CBLC-1,AKAP5,DUT,RHAG,GRHL1,SLC2A3,LRPPRC |
Protein Function
PRKRA has several biochemical functions, for example, alditol:NADP+ 1-oxidoreductase activity,electron carrier activity,phenanthrene-9,10-epoxide hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRKRA itself. We selected most functions PRKRA had, and list some proteins which have the same functions with PRKRA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| alditol:NADP+ 1-oxidoreductase activity | AKR7A2,AKR1B7,AKR1B1,AKR1C21,AKR7A5,ADH4,Akr1b3,AKR1C3,AKR1B8,AKR1A1 |
| electron carrier activity | ACAD9,FDX1,UGDH,COX7A3,ADH5,GRX2,FDX1L,GPX2,AOX3L1,ACADS |
| phenanthrene-9,10-epoxide hydrolase activity | AKR7A5,AKR7A2 |
Interacting Protein
PRKRA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRKRA here. Most of them are supplied by our site. Hope this information will be useful for your research of PRKRA.
TARBP2;LYAR;ZMAT3;NS;EIF2AK2
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