PPP3R1

  • Official Full Name

    protein phosphatase 3, regulatory subunit B, alpha

  • Overview

    PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and

  • Synonyms

    PPP3R1;protein phosphatase 3, regulatory subunit B, alpha;calcineurin subunit B type 1;calcineurin B;type I (19kDa);CALNB1;CNB;CNB1;protein phosphatase 2B regulatory subunit B alpha;CANB1_HUMAN;Cna2;PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform;Protein phosphatase 2B regulatory subunit 1;Protein phosphatase 3 regulatory subunit B alpha isoform 1;OTTHUMP00000201952;OTTHUMP00000201960;OTTHUMP00000201961;calcineurin B, type I (19kDa);protein phosphatase 3 (formerly 2B), regulato

Recombinant Proteins

  • Human
  • Mouse
  • Rat
  • Chicken
  • E. coli
  • E.coli
  • Mammalian Cells
  • Insect Cells
  • HEK293
  • GST
  • His
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
PPP3R1-1923H Recombinant Human PPP3R1 protein, GST-tagged E. coli Human GST
PPP3R1-1119H Recombinant Human PPP3R1 protein, His & GST-tagged E.coli Human GST&His Gly2~Val170
PPP3R1-13269M Recombinant Mouse PPP3R1 Protein Mammalian Cells Mouse His
PPP3R1-27208TH Recombinant Human PPP3R1, His-tagged E.coli Human His 170 amino acids
PPP3R1-3471H Recombinant Human PPP3R1, His-tagged E.coli Human His
PPP3R1-4641R Recombinant Rat PPP3R1 Protein Mammalian Cells Rat His
PPP3R1-5946C Recombinant Chicken PPP3R1 Mammalian Cells Chicken His
PPP3R1-7366H Recombinant Human PPP3R1 protein(Gly2-Val170), His-tagged Insect Cells Human His 2-170 a.a.
PPP3R1-001HCL Recombinant Human PPP3R1 cell lysate Insect Cells Human Non
PPP3R1-2158H Recombinant Human PPP3R1 Protein (Met1-Val170), N-His tagged E.coli Human His Met1-Val170
PPP3R1-4300R Recombinant Rat PPP3R1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
PPP3R1-4300R-B Recombinant Rat PPP3R1 Protein Pre-coupled Magnetic Beads HEK293 Rat
PPP3R1-5969H Recombinant Human PPP3R1 Protein (Gly2-Val170), N-GST tagged E.coli Human GST Gly2-Val170
PPP3R1-7043M Recombinant Mouse PPP3R1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
PPP3R1-7043M-B Recombinant Mouse PPP3R1 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PPP3R1 involved in several pathways and played different roles in them. We selected most pathways PPP3R1 participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Apoptosis DERL3,CAPN1B,GZMC,BCL2L1,NFKB1,YWHAQ,NTRK1,BCL2,NGF,IL1B2
    Tuberculosis H2-AA,CALM1,IL23,TNF,RFXAP,MAPK1,CAMK2D,TLR2,C3,PPP3CC
    Axon guidance DUSP9,RHOD,SEMA5B,RGS3,SPRED2,HRAS,HFE2,RHOGA,GDNF,RAC2
    Wnt signaling pathway WNT8A,ROCK2A,FZD2,MAPK9,RHOAB,NFATC4,WNT5B,CAMK2D2,CCND3,FZD1
    cGMP-PKG signaling pathway PRKG1,PIK3R5,PIK3CA,SLC25A5,PDE2A,CALM3,ATP1A4,AKT1,GNAI3,VDAC3
    Amyotrophic lateral sclerosis (ALS) CCS,SOD1,PPP3R2,MAP2K3,GPX1,TNFRSF1A,TOMM40,NEFL,BCL2L1,GRIN2C
    Oxytocin signaling pathway NFATC2,TRPM2,PIK3CG,PRKAB2,CACNB3,ACTG1,CACNG4,PLCB4,PRKCG,PIK3CA
    MAPK signaling pathway CACNB1,FGF11,RPS6KA3A,HSPA2,ARR3A,MAP2K1,GRB2A,LAMTOR3,MAPK14A,NLK1
    T cell receptor signaling pathway PIK3CD,CD8B,IFNG,AKT1,NFATC3,PTPN6,PIK3R2,NFATC2,MAPK12,NCK2

    Protein Function

    PPP3R1 has several biochemical functions, for example, calcium ion binding,calcium-dependent protein serine/threonine phosphatase activity,calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3R1 itself. We selected most functions PPP3R1 had, and list some proteins which have the same functions with PPP3R1. You can find most of the proteins on our site.

    Function Related Protein
    protein domain specific binding CEP68,NFE2L2,FOXA2,DIXDC1,XPA,TUBB,PHRF1,NLRP1,ARFIP1,PICK1
    calcium-dependent protein serine/threonine phosphatase activity PPP3CB,NETO2,CAMK2G
    calcium ion binding PLA2G2A,CABYR,SLIT1A,CETN2,TBC1D9B,PLA2G4B,NELL2,PCDHGB6,RCN3,ACTN3B
    protein binding SEPHS1,EIF4EA,LGALS14,ITGB2,SEC23IP,RPGR,HSPB7,IFT46,RASGRP3,MUTYH
    calmodulin binding CAMK1G,RASGRF2,MYO7A,ATP2B4,MYH13,STRN,OBSCN,PDE1B,RYR2,ADD2

    Interacting Protein

    PPP3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3R1.

    PPP3CA;BCL2;CALM1;MAP3K5;NAP1L2;USP14;IQCB1

    Resources

    Research Area

    Calcium-binding Proteins and Related Molecules
    Phosphatases in the Akt Pathway
    Wnt Intracellular Signaling
    C-type Lectin Receptors

    References

    • Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).
    • Pinheiro, CS; Staub, O; et al. Characterization and binding affinities of SmLANP: A new Schistosoma mansoni member of the ANP32 family of regulatory proteins. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 165:95-102(2009).

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