PPP1CB
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Official Full Name
protein phosphatase 1, catalytic subunit, beta isozyme -
Overview
Type 1 protein Ser/Thr phosphatases (PP1) have a high specific activity against phosphorylase, and are resistant to okadaic acid up to concentrations of 50 nM, but sensitive to Inhibitor-2 and microcystin LR. -
Synonyms
PPP1CB;protein phosphatase 1, catalytic subunit, beta isozyme;protein phosphatase 1, catalytic subunit, beta isoform;serine/threonine-protein phosphatase PP1-beta catalytic subunit;PP 1B;PP1beta;protein phosphatase 1-beta;protein phosphatase 1-delta;protein phosphatase 1, catalytic subunit, delta isoform;serine/threonine protein phosphatase PP1-beta catalytic subunit;PP-1B;PPP1CD;MGC3672
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Chicken
- HEK293
- Sf9 Cells
- Mammalian Cells
- E.coli
- Human Cells
- DDK
- Myc
- GST
- His
- Non
- Avi
- Fc
- Flag
Involved Pathway
PPP1CB involved in several pathways and played different roles in them. We selected most pathways PPP1CB participated on our site, such as mRNA surveillance pathway,cGMP-PKG signaling pathway,cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | DRD1A,MAPK8,ROCK1,ATP1B3,GHSR,GHRL,NPY1R,GRIN2C,PIK3CG,EP300 |
| Dopaminergic synapse | GRIA2,DDC,CALM1,KIF5C,CREB5,GRIA3,PPP2CA,DRD3,PPP2R3C,PRKCG |
| Insulin signaling pathway | PRKACB,EIF4E2RS1,PRKCI,GYS1,HK1,HK3,FBP2,MAP2K2A,PHKG1A,HKDC1 |
| Hippo signaling pathway | WNT5B,INADL,PPP2CA,ID2,FZD7,TGFBR2,JUB,DLG3,SCRIB,FZD2 |
| Long-term potentiation | CAMK2B,CALML5,PRKACG,HRAS,GNAQ,PLCB2,CALM2,RPS6KA6,CAMK2A,GRIN2B |
| Regulation of Actin Cytoskeleton | FGF17,MAP2K1,ROCK1,MYL9A,PPP1R12B,PAK2A,FGF1A,MYL1,FGFR1,PIKFYVE |
| Alcoholism | HIST1H4D,HIST3H2A,CAMKK1,HIST1H2AJ,GNG12,SHC1,ADORA2B,CREB3L4,MAOB,HIST1H4C |
| Proteoglycans in cancer | RPS6,HSPG2,FLNC,WNT10B,WNT1,ARHGEF1,WNT3A,ITGA5,CD44,TWIST2 |
| Herpes simplex infection | EIF2AK4,CDK1,TAF4B,MYD88,STAT2,MAVS,IFNA4,MHC2DCB,TRAF1,Fasl |
Protein Function
PPP1CB has several biochemical functions, for example, metal ion binding,myosin phosphatase activity,myosin-light-chain-phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1CB itself. We selected most functions PPP1CB had, and list some proteins which have the same functions with PPP1CB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| phosphatase activity | PTPRO,PTPRNA,DUSP3B,DUSP27,MTMR7A,DUSP13A,SACM1LB,CTDSPLA,DUSP11,PTPN4B |
| protein binding | APOBEC3G,CLINT1,RUVBL1,MLF1IP,TRMT12,NLRP12,PIDD1,POLB,MRC1,IMPDH2 |
| protein kinase binding | TEX14,RICTOR,FAM83A,SMAD1,ADIPOR1,LIPE,PTPRJ,NSF,ITGB2,NEK6 |
| metal ion binding | CHORDC1B,ATP13A5,CYP2AA7,FAM20B,ATP1A1A.4,TGM2,ZC3H7A,CAHZ,ZNF669,ZSWIM4 |
Interacting Protein
PPP1CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1CB.
SH2D4A;PPP1R7;PPP1R16A;PPP1R13L;BRCA1;PPP1R12A
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References
- OMAY, SB; NISHIKAWA, M; et al. DECREASED EXPRESSION OF PROTEIN PHOSPHATASE TYPE 2A IN HL-60 VARIANT (HL-6ORA) CELLS RESISTANT TO INDUCTION OF CELL-DIFFERENTIATION BY ALL-TRANS-RETINOIC ACID. EXPERIMENTAL HEMATOLOGY 23:244-251(1995).
