PPIE
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Official Full Name
peptidylprolyl isomerase E (cyclophilin E) -
Overview
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was shown to possess PPIase and protein folding activities, and it also exhibits RNA-binding activity. Alternative splicing results in multiple transcript variants. A related pseudogene, which is also located on chromosome 1, has been identified. -
Synonyms
PPIE;peptidylprolyl isomerase E (cyclophilin E);peptidyl-prolyl cis-trans isomerase E;cyclophilin 33;cyclophilin E;CyP 33;MGC3736;MGC111222;peptidyl prolyl cis trans isomerase E;peptidylprolyl isomerase E;isoform 1;PPIase E;rotamase E;cycloph
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- GST
- His
- T7
- His&T7
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PPIE involved in several pathways and played different roles in them. We selected most pathways PPIE participated on our site, such as DNA Repair,Dual incision in TC-NER,Formation of TC-NER Pre-Incision Complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPIE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcription-Coupled Nucleotide Excision Repair (TC-NER) | GPS1,COPS7B,COPS8,COPS7A,COPS6,COPS2,COPS3,COPS4,ERCC8,ZNF830 |
| DNA Repair | USP10,RAD9B,ACTL6A,RNF168,PPP4CA,PARP2,WRN,EYA4,BRE,CLSPN |
| Nucleotide Excision Repair | GTF2H2,ACTR5,PCNA,INO80B,BIVM-ERCC5,GTF2H2C,ERCC1,RFC3,COPS7B,RPA1 |
| Dual incision in TC-NER | ERCC8,TCEA1,ZNF830,KIAA1530,ZFP830,DDB1 |
| Gap-filling DNA repair synthesis and ligation in TC-NER | ERCC8,KIAA1530,ZNF830,TCEA1,DDB1,ZFP830 |
| Formation of TC-NER Pre-Incision Complex | TCEA1,ZNF830,KIAA1530,ERCC8,COPS4,GPS1,COPS8,ZFP830,COPS7A,DDB1 |
| Spliceosome | HNRNPM,HNRPK,HSPA1B,HSPA6,SR140,PRPF18,PRPF4,CWC15,SNRNP27,SNRPA |
Protein Function
PPIE has several biochemical functions, for example, RNA binding,cyclosporin A binding,nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPIE itself. We selected most functions PPIE had, and list some proteins which have the same functions with PPIE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cyclosporin A binding | PPIF,PPIG,PPIC,PPID,PPIH |
| poly(A) RNA binding | NSBP1,RPS19,PRPF40A,LGALS1,HNRNPD,MRPS14,RPS28,SUGP1,ZFML,HERC5 |
| peptidyl-prolyl cis-trans isomerase activity | PPIAB,FKBP14,FKBP1AB,PPIFA,CWC27,PPIL4,PPIA,PPIG,PPIF,PPIAL4B |
| RNA binding | ADAD1,NOL4,RPL4,DCP2,RPS14,NOVA2,EIF4E1C,KHDC3L,ATXN1L,TERT |
| protein binding | RASL11A,TBCB,PDCD10,SGPL1,PELI1,DDRGK1,NMB,NOD1,PMP22,CTBP1 |
| nucleotide binding | DAZAP1,HPRT1,SRSF1A,ABCG2B,RASL10B,TUBA2,IFT22,ATP1A1A.1,PPRC1,ABCA5 |
Interacting Protein
PPIE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPIE here. Most of them are supplied by our site. Hope this information will be useful for your research of PPIE.
XAB2;KMT2A;Snw1;HIST1H3D;trx;Cdc5l;Prpf8
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References
- Liao, JC; Chiu, CS; et al. Characterization of a novel Cyclophilin-type peptidylprolyl isomerase protein from sweet potato storage roots. BOTANICAL STUDIES 53:315-324(2012).
- Xia, HC; Lv, HG; et al. Cloning and characterization of peptidylprolyl isomerase B in the silkworm, Bombyx mori. AFRICAN JOURNAL OF BIOTECHNOLOGY 8:7116-7124(2009).
