PELI1
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Official Full Name
pellino E3 ubiquitin protein ligase 1 -
Synonyms
PELI1;pellino E3 ubiquitin protein ligase 1;8827;ENSG00000197329;2p13.3;MGC50990, DKFZp686C18116;E3 ubiquitin-protein ligase pellino homolog 1;E3 ubiquitin-protein ligase pellino homolog 1;pellino-1;pellino homolog 1;protein pellino homolog 1;pellino-related intracellular-signaling molecule
Recombinant Proteins
- Human
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cells
- Insect Cells
- HEK293
- GST
- His
- His&GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PELI1 involved in several pathways and played different roles in them. We selected most pathways PELI1 participated on our site, such as Activated TLR4 signalling,Cytokine Signaling in Immune system,IRAK1 recruits IKK complex, which may be useful for your reference. Also, other proteins which involved in the same pathway with PELI1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Interleukin-1 signaling | NOD1,TNIP2,PELI2,PELI3,IRAK3,IL1RN |
| Activated TLR4 signalling | TIRAP,SAA1,MAPK14,DHX9,DUSP3,CHST13,APPB,MAPKAPK2B,S100B,CREB1B |
| MyD88 cascade initiated on plasma membrane | DUSP3B,AGER,PELI3,S100A12,DHX9,ALCAMB,TNIP2,PELI2,S100B,CHST13 |
| Cytokine Signaling in Immune system | MARK3,EGR1,TRIM22,CSH1,TRIM8,NRG2A,PHB,DUSP5,HLA-DQB2,EIF4G2A |
| IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation | PELI2,PELI3 |
| Innate Immune System | PCBP2,WIPF3,BFB,DUSP3B,DEFB4A,TREX1,DDOST,BTR22,CRP,PANX1 |
| Immune System | ERAP2,KIF2A,DZIP3,XAF1,RNF41,NLRP4E,PVRL2L,CISH,SUGT1,IFI6 |
| IRAK1 recruits IKK complex | PELI3,PELI2 |
Protein Function
PELI1 has several biochemical functions, for example, ligase activity,protein binding,ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PELI1 itself. We selected most functions PELI1 had, and list some proteins which have the same functions with PELI1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | MAP3K11,GCH1,NFU1,ERCC8,RAF1,PIGK,FGF10,GRM6,PRDM16,GTSE1 |
| ligase activity | UBE2NB,BTR22,RNF135,ACSL1,CCNB1IP1,TRIM37,MARCH10,UBE1Y1,TRIM32,SYVN1 |
| ubiquitin protein ligase activity | RNF2,RNF7,MARCH1,CCNB1IP1,RBX1,TRIM32,UBE2KB,TRIM2,MSL2B,MED23 |
Interacting Protein
PELI1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PELI1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PELI1.
IRAK1;VAC14;TRIP13;IRAK4;UBA1;UBE2N;SRPK2;UBE2V1;SRPK1;Rel;TFAP2A;IRS1;TRAF6
Resources
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References
- Giegerich, AK; Kuchler, L; et al. Autophagy-dependent PELI3 degradation inhibits proinflammatory IL1B expression. AUTOPHAGY 10:1937-1952(2014).
- Park, HY; Go, H; et al. Pellino 1 promotes lymphomagenesis by deregulating BCL6 polyubiquitination. JOURNAL OF CLINICAL INVESTIGATION 124:4976-4988(2014).
