PDE5A
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Official Full Name
phosphodiesterase 5A, cGMP-specific -
Overview
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
PDE5A;phosphodiesterase 5A, cGMP-specific;CN5A;PDE5;CGB-PDE;cGMP-specific 3,5-cyclic phosphodiesterase;phosphodiesterase isozyme 5;cGMP-specific phosphodiesterase PDE5A2;cGMP-specific phosphodiesterase type 5A;cGMP-binding cGMP-specific 3,5-cyclic nucleotide phosphodiesterase
Recombinant Proteins
- Human
- Mouse
- Rat
- Bovine
- E.coli
- Mammalian Cells
- Sf9 Cells
- Insect Cells
- HEK293
- GST
- His
- Non
- DDK
- Myc
- Avi
- Fc
Involved Pathway
PDE5A involved in several pathways and played different roles in them. We selected most pathways PDE5A participated on our site, such as Purine metabolism,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cGMP-PKG signaling pathway | SRF,PPP1CB,INS1,CREB3L3,IRS4,PIK3CG,SLC25A31,NFATC2,PPP3CB,Adcy4 |
| Purine metabolism | PAICS,NME2B.2,CANT1B,PPAT,Adcy4,PDE6A,PNP,PNP5B,POLR3GL,PRPS2 |
Protein Function
PDE5A has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity,3,5-cyclic-nucleotide phosphodiesterase activity,cGMP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE5A itself. We selected most functions PDE5A had, and list some proteins which have the same functions with PDE5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cGMP binding | PRKG1A,PDE6G,PDE6C,PDE10A,PRKG1,CNGA3,PDE2A,CNGA4,CNGA2,PDE6H |
| 3,5-cyclic-GMP phosphodiesterase activity | PDE6H,PDE10A,PDE6C,PDE6A,PDE6G,PDE6B,PDE11A,PDE9A |
| metal ion binding | ARAP3,GNA11,RARGB,CYP2C70,ZNF295,NT5C2L1,GBGT1,NRXN3,DPEP2,GTF3A |
| 3,5-cyclic-nucleotide phosphodiesterase activity | PDE4D,PDE6D,PDE5AB,PDE3B,PDE11A,PDE9A,PDE10A,PDE8B,PDE8A |
Interacting Protein
PDE5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE5A here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE5A.
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