PAICS
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Official Full Name
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -
Overview
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PAICS;phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase;PAIS;multifunctional protein ADE2;ADE2H1;AIRC;ADE2;AIR carboxylase;DKFZp781N1372;MGC1343;MGC5024;Phosphoribosylaminoimidazole carboxylase;PUR6_HUMAN;SAICAR synthetase;multifunctional protein ADE2H1
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
Involved Pathway
PAICS involved in several pathways and played different roles in them. We selected most pathways PAICS participated on our site, such as Biosynthesis of antibiotics,Metabolic pathways,Metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAICS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine ribonucleoside monophosphate biosynthesis | ADSS,ADSL,ADSSL1 |
| Metabolism | GLYATL2,SLC5A6B,ABHD4,OSBP,CYP4T8,CLPS,AMDHD1,NOSTRIN,CYP3C1,CYP2A7 |
| Purine metabolism | PDE3B,AK2,IMPDH1A,GMPS,AMPD1,PDE4D,ADKB,PRPS1A,POLR2E,GUK1A |
| Biosynthesis of antibiotics | GPR19,AGXT,DAO1,DBT,ECHS1,CTH,DAO,AK8,ANI_1_2390104,CYP51A1 |
| Metabolism of nucleotides | ADK,ADSL,DCK,TYMP,ADSS,ITPA,DHODH,NUDT5,DPYDA.1,AK7A |
| Metabolic pathways | NADK2,PIGA,DPAGT1,UOX,MOGAT3,GLUD1B,NDUFA5,PNLIPRP1,ALG3,ACAD8 |
Protein Function
PAICS has several biochemical functions, for example, ATP binding,identical protein binding,phosphoribosylaminoimidazole carboxylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PAICS itself. We selected most functions PAICS had, and list some proteins which have the same functions with PAICS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PPAP2B,MFF,ATRX,COL3A1,SMARCA4,UNG,CLEC16A,PDE9A,KARS,HSPA1A |
| identical protein binding | DRD4,KCTD13,RAD51,UGP2,LCK,LECT2,TRIP10,TFRC,NOXO1,INHBA |
| ATP binding | ABCE1,TNK1,CAMKV,SRR,CAMK1DB,ACVR1,GCLC,DHX35,ADCK2,SETX |
Interacting Protein
PAICS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAICS here. Most of them are supplied by our site. Hope this information will be useful for your research of PAICS.
FXR2;NUDT18;L3MBTL2;NIF3L1;SGK1;EIF1B;EPB41;TIMP2;MCC
Resources
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References
- Duval, N; Luhrs, K; et al. Genetic and metabolomic analysis of AdeD and AdeI mutants of de novo purine biosynthesis: Cellular models of de novo purine biosynthesis deficiency disorders. MOLECULAR GENETICS AND METABOLISM 108:178-189(2013).
- Ng, A; Uribe, RA; et al. Zebrafish mutations in gart and paics identify crucial roles for de novo purine synthesis in vertebrate pigmentation and ocular development. DEVELOPMENT 136:2601-2611(2009).
