PADI2
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Official Full Name
peptidyl arginine deiminase, type II -
Overview
This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type II enzyme is the most widely expressed family member. Known substrates for this enzyme include myelin basic protein in the central nervous system and vimentin in skeletal muscle and macrophages. This enzyme is thought to play a role in the onset and progression of neurodegenerative human disorders, including Alzheimer disease and multiple sclerosis, and it has also been implicated in glaucoma pathogenesis. This gene exists in a cluster with four other paralogous genes. -
Synonyms
PADI2;peptidyl arginine deiminase, type II;protein-arginine deiminase type-2;KIAA0994;PDI2;OTTHUMP00000044625;PAD 2;PAD H19;PADI 2;PADI2 protein;PDI 2;Peptidlyarginine deiminase type II;Peptidyl arginine deiminase II;Peptidyl arginine deiminase type II;Peptidylarginine deiminase II;Protein arginine deiminase;Protein arginine deiminase type 2;Protein arginine deiminase type II;OTTHUMP00000002403;OTTHUMP00000002404;protein-arginine deiminase type II;PAD2;PAD-H19
Recombinant Proteins
- Human
- Zebrafish
- Rhesus macaque
- Rat
- Mouse
- Cynomolgus
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- HEK293
- E. coli
- Insect Cells
- Baculovirus-Insect cells
- Insect cell
- HEK293T
- Yeast
- Mamanlian cells
- Mammalian cells
- His&GST
- Flag
- His
- GST
- Myc&DDK
- Twin Strep
- Strep
- His&SUMO
- His&Fc&Avi
- His&Myc
Involved Pathway
PADI2 involved in several pathways and played different roles in them. We selected most pathways PADI2 participated on our site, such as Chromatin modifying enzymes,Chromatin organization,protein citrullination, which may be useful for your reference. Also, other proteins which involved in the same pathway with PADI2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chromatin organization | EPC1,PBRM1,AEBP2,KDM3A,CAPNS2,ASH2L,RBB4L,ELP4,BRPF1,KDM4A |
| Chromatin modifying enzymes | VPS72,PADI1,USP22,PRDM16,KDM3B,JHDM1D,KDM1B,CHD4A,KDM1A,KANSL2 |
| protein citrullination | PADI6,PADI3,PADI1,PADI4 |
Protein Function
PADI2 has several biochemical functions, for example, calcium ion binding,estrogen receptor binding,protein-arginine deiminase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PADI2 itself. We selected most functions PADI2 had, and list some proteins which have the same functions with PADI2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein-arginine deiminase activity | PADI1,PADI3,PADI4,PADI6 |
| estrogen receptor binding | NKX3-1,ISL1,PPID,DYX1C1,TAF10,NCOA1,WIPI1,STRN,CCDC62,TRIP4 |
| calcium ion binding | TPM4,OCM,C1RA,CETN4,PADI3,NCS1B,EFCAB4B,EFEMP2,FBN1,FKBP14 |
Interacting Protein
PADI2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PADI2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PADI2.
MYC
Resources
Research Area
Peptidylarginine DeiminasesMultiple Sclerosis and Myelin Related Molecules
Amino Acid Delivery
Related Services
Related Products
References
- Hsu, PC; Liao, YF; et al. Vimentin Is Involved in Peptidylarginine Deiminase 2-Induced Apoptosis of Activated Jurkat Cells. MOLECULES AND CELLS 37:426-434(2014).
- Chang, XT; Xia, YF; et al. PADI2 Is Significantly Associated with Rheumatoid Arthritis. PLOS ONE 8:-(2013).
