NUDT1
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Official Full Name
nudix (nucleoside diphosphate linked moiety X)-type motif 1 -
Overview
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. -
Synonyms
NUDT1;nudix (nucleoside diphosphate linked moiety X)-type motif 1;MTH1;7,8-dihydro-8-oxoguanine triphosphatase;7;8 dihydro 8 oxoguanine triphosphatase;8 oxo 7;8 dihydrodeoxyguanosine triphosphatase;8 dihydroguanosine triphosphatase;8 oxo dGTPase
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rhesus macaque
- Rat
- E.coli
- Mammalian Cells
- HEK293
- Yeast
- Insect Cells
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
NUDT1 involved in several pathways and played different roles in them. We selected most pathways NUDT1 participated on our site, such as Metabolism,Metabolism of nucleotides,Phosphate bond hydrolysis by NUDT proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NUDT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Phosphate bond hydrolysis by NUDT proteins | NUDT5,NUDT18,NUDT15,NUDT16 |
| Metabolism of nucleotides | AK8,GRX2,TM9SF1,GLRX,ADSL,TYMP,ADK,DPYDA.1,AK7A,NUDT16 |
| Metabolism | DPEP1,CYP3A7-CYP3AP1,STAB2,FIG4,ARV1,VAPB,CYP2U1,NUDT15,SLC5A4,NUBP1 |
Protein Function
NUDT1 has several biochemical functions, for example, 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity,8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity,ATP diphosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NUDT1 itself. We selected most functions NUDT1 had, and list some proteins which have the same functions with NUDT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | RGS16,MRPL13,SERPINA1A,RNF126,KRTAP10-11,DDX41,PPFIA4,IL2RG,SHMT1,MYD88 |
| metal ion binding | MOBKL2A,AMPD3,FGD3,HAGH,SMAD7,ZNF550,REPIN1,CYP39A1,ZSCAN2,ADAP2 |
| 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity | NUDT15 |
| GTPase activity | GNAT1,RAB32A,EFTUD1,RAB25,ARL4C,SRPR,DNM1A,MTIF2,EEF1A1L2,GPN1 |
| NOT m7G(5)pppN diphosphatase activity | NUDT4,NUDT5,NUDT7,NUDT16L1 |
| snoRNA binding | NHP2,UTP6,HEATR1,TBL3,UTP15,NOP10,NUDT5,NOP56,NUDT4,IMP3 |
| 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity | NUDT19,DOM3Z,NUDT15 |
Interacting Protein
NUDT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NUDT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NUDT1.
HEL-S-5;NTHL1;RNMTL1;s-crizotinib;sch51344;GABARAP;GABARAPL2;MAP1LC3B;GABARAPL1
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References
- Albayrak, O; Putter, C; et al. Common obesity risk alleles in childhood attention-deficit/hyperactivity disorder. AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS 162B:295-305(2013).
- Wilson, GRS; Morton, JD; et al. The locus for an inherited cataract in sheep maps to ovine chromosome 6. MOLECULAR VISION 18:1384-1394(2012).
