NPHS2
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Official Full Name
podocin -
Overview
Podocin (NPHS2 protein) is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. It is a hairpin like integral membrane protein with intracellular N and C termini. Podocin is located at the insertion site of the slit membrane, and is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton. -
Synonyms
NPHS2;podocin;PDCN;SRN1
Recombinant Proteins
- Human
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- Myc&DDK
- Non
- His&Fc&Avi
- Flag
- GST
Involved Pathway
NPHS2 involved in several pathways and played different roles in them. We selected most pathways NPHS2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NPHS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NPHS2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by NPHS2 itself. We selected most functions NPHS2 had, and list some proteins which have the same functions with NPHS2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
NPHS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NPHS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NPHS2.
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References
- Holmberg, C; Jalanko, H; et al. Congenital nephrotic syndrome and recurrence of proteinuria after renal transplantation. PEDIATRIC NEPHROLOGY 29:2309-2317(2014).
- Kimura, J; Ichii, O; et al. Close Relations between Podocyte Injuries and Membranous Proliferative Glomerulonephritis in Autoimmune Murine Models. AMERICAN JOURNAL OF NEPHROLOGY 38:27-38(2013).
