NMUR2
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Official Full Name
neuromedin U receptor 2 -
Overview
This gene encodes a protein from the G-protein coupled receptor 1 family. This protein is a receptor for neuromedin U, which is a neuropeptide that is widely distributed in the gut and central nervous system. This receptor plays an important role in the regulation of food intake and body weight. -
Synonyms
NMUR2;neuromedin U receptor 2;NMU2R;neuromedin-U receptor 2;G-protein coupled receptor FM-4;G-protein coupled receptor TGR-1;growth hormone secretagogue receptor family, member 4;FM4;FM-4;TGR1;TGR-1;NMU-R2
Recombinant Proteins
- Mouse
- Rat
- Human
- Mus musculus
- Bovine
- Mammalian Cells
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- E.coli
- His
- Non
- His&Fc&Avi
- GST
Involved Pathway
NMUR2 involved in several pathways and played different roles in them. We selected most pathways NMUR2 participated on our site, such as Neuroactive ligand-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMUR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Neuroactive ligand-receptor interaction | GRIA2A,MTNR1AA,TAAR1B,HTR2A,LOC100328615,P2RY6,MAS1,CHRNB2,GALR1,BRS3 |
Protein Function
NMUR2 has several biochemical functions, for example, G-protein coupled receptor activity,GTP binding,intracellular calcium activated chloride channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMUR2 itself. We selected most functions NMUR2 had, and list some proteins which have the same functions with NMUR2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTP binding | RAB1,RAB14L,DNM1A,GTPBP5,PPP1CA,RAB12,RAB41,TUBA1C,IRGE4,RAN |
| intracellular calcium activated chloride channel activity | ANO9,TTYH3,ANO2,CLCA2,ANO8,ANO6,CLCA1,CLCA4,ANO4,ANO7 |
| G-protein coupled receptor activity | GPR31,RHO,TAAR13D,VMN1R50,OR52B6,MRGPRF,V2RH14,OR4D6,OLFR147,CD97 |
| protein binding | DYNLRB1,UBE2U,APEH,RSPH3,CDA,MTNR1B,FAM113B,PTK7,ZFHX3,UTP3 |
| neuromedin U receptor activity | NMUR1 |
Interacting Protein
NMUR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMUR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMUR2.
TCF4;TRAF2;ADAMTSL4;NOTCH2NL
Resources
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References
- Chen, RX; Liu, F; et al. Neuromedin S Increases L-type Ca2+ Channel Currents Through G(i)alpha-protein and Phospholipase C-dependent Novel Protein Kinase C Delta Pathway in Adult Rat Ventricular Myocytes. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 30:618-630(2012).
- Zhang, YA; Jiang, DS; et al. Activation of neuromedin U type 1 receptor inhibits L-type Ca2+ channel currents via phosphatidylinositol 3-kinase-dependent protein kinase C epsilon pathway in mouse hippocampal neurons. CELLULAR SIGNALLING 22:1660-1668(2010).
