NEK2
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Official Full Name
NIMA (never in mitosis gene a)-related kinase 2 -
Overview
NEK2 is a serine/threonine kinase involved in mitotic regulation. NEK2 also known as serine/threonine protein kinase Nek2, NimA-related protein kinase 2, and HSPK21, can be expressed as 3 different isoforms as a result of alternative splicing.. The predic -
Synonyms
NEK2;NIMA (never in mitosis gene a)-related kinase 2;serine/threonine-protein kinase Nek2;HsPK 21;NEK2A;NLK1;nimA-like protein kinase 1;nimA-related protein kinase 2;HsPK21
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- Chicken
- Rhesus macaque
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Insect (sf21)
- HEK293
- GST
- His
- Non
- His&Fc&Avi
Involved Pathway
NEK2 involved in several pathways and played different roles in them. We selected most pathways NEK2 participated on our site, such as APC-Cdc20 mediated degradation of Nek2A,APC/C-mediated degradation of cell cycle proteins,APC/C:Cdc20 mediated degradation of mitotic proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Anchoring of the basal body to the plasma membrane | CETN2,NEDD1,DCTN2,CEP135,TMEM216,CEP63,CEP89,DCTN1,CCP110,TTBK2 |
| APC/C-mediated degradation of cell cycle proteins | ANAPC10,PSMD5,PSMA8,PSMD9,AURKB,PSMD10,UBE2C,PSME3,CDK2,PSMD14 |
| Cell cycle | WEE1,RBBP8,TOP2A,NCAPG,GADD45A,MSH4,CDC26,E2F2,DBF4,CENPH |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | PSME3,PSMA8,PSMD9,PSMD10,PSMD14,ANAPC10,PSMD5,UBE2C |
| Assembly of the primary cilium | TTC30A2,BBS5,CLASP1A,BBS12,ARL13B,SSNA1,PROL1,TRAF3IP1,CCDC41,IFT46 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | ANAPC10,PSMA8,PSME3,PSMD10,PSMD14,PSMD5,PSMD9,UBE2C |
| APC-Cdc20 mediated degradation of Nek2A | ANAPC10,UBE2C |
| APC/C:Cdc20 mediated degradation of mitotic proteins | UBE2C,PSMD9,PSMD5,PSME3,PSMD10,ANAPC10,PSMD14,PSMA8 |
Protein Function
NEK2 has several biochemical functions, for example, ATP binding,metal ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK2 itself. We selected most functions NEK2 had, and list some proteins which have the same functions with NEK2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein phosphatase binding | AP3B1,DRD1A,MET,HSF4,PPARG,JAK1,JAK3,MAP2K7,CSK,GNB2L1 |
| ATP binding | PANK1B,CSNK1D,UBE2D4,DGKB,STK26,BSK146,SMG1,FDXACB1,MTOR,CHD4A |
| metal ion binding | CYP2AA12,RXFP1,ACVRL1,ELOF1,PDE4D,ATF7,TRIT1,GLIS2,RASA3,ZBTB25 |
| protein serine/threonine kinase activity | SIK2A,BCR,TLK1B,RIOK1,ACVR1BA,MAP4K1,RPS6KA5,SLC14A2,KSR2,ADCK2 |
| protein kinase activity | PDPK1B,MAP3K12,EPHB3A,MAPK14B,EEF2K,DCLK2,EK1,EPHB2B,LMTK2,INSRB |
| protein binding | SNX12,SETX,KHDC1B,HIST1H2BB,PLP2,FGFR4,LDHAL6B,ATG9A,FAM125B,C1QTNF9B-AS1 |
Interacting Protein
NEK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK2.
NEK11;Cdc23;Cdc16;Cdc26;CDC16;cdc27;CDC27
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References
- Mbom, BC; Siemers, KA; et al. Nek2 phosphorylates and stabilizes beta-catenin at mitotic centrosomes downstream of Plk1. MOLECULAR BIOLOGY OF THE CELL 25:977-991(2014).
- Kim, S; Hwang, SK; et al. Fanconi anemia complementation group A (FANCA) localizes to centrosomes and functions in the maintenance of centrosome integrity. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 45:1953-1961(2013).
