NCBP2
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Official Full Name
nuclear cap binding protein subunit 2, 20kDa -
Overview
The product of this gene is a component of the nuclear cap-binding protein complex (CBC), which binds to the monomethylated 5 cap of nascent pre-mRNA in the nucleoplasm. The encoded protein has an RNP domain commonly found in RNA binding proteins, and contains the cap-binding activity. The CBC promotes pre-mRNA splicing, 3-end processing, RNA nuclear export, and nonsense-mediated mRNA decay. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NCBP2;nuclear cap binding protein subunit 2, 20kDa;nuclear cap binding protein subunit 2, 20kD;nuclear cap-binding protein subunit 2;Cbc2;CBP20;NIP1;20 kDa nuclear cap binding protein;Cell proliferation inducing gene 55 protein;NCBP 2;NCBP 20 kDa subunit;NCBP interacting protein 1;Nuclear cap binding protein subunit 2;PIG55;OTTHUMP00000208152;OTTHUMP00000208153;OTTHUMP00000208155;OTTHUMP00000208156;OTTHUMP00000208157;OTTHUMP00000208158;NCBP-interacting protein 1;20 kDa nuclear cap-binding pr
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mammalian Cell
- E.coli
- HEK293
- HEK293T
- His
- Non
- His&Fc&Avi
- GST
- Myc&DDK
Involved Pathway
NCBP2 involved in several pathways and played different roles in them. We selected most pathways NCBP2 participated on our site, such as RNA transport,mRNA surveillance pathway,Spliceosome, which may be useful for your reference. Also, other proteins which involved in the same pathway with NCBP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | SMN1,SIP1,PEAK1,EIF4EA,BAT1,PHAX,NXT1,UBE2IA,SUMO2B,EIF1AXB |
| Spliceosome | TXNL4A,CHERP,CDC5L,SRSF2A,SF3A2,PRP19,U2AF2B,SRSF5A,PQBP1,THOC4 |
| mRNA surveillance pathway | SYMPK,PABPN1L,PPP2R5E,PPP2R5C,FIP1L1B,PPP2R5D,BCL2L2-PABPN1,PPP2CA,MSI2A,PPP2R5A |
Protein Function
NCBP2 has several biochemical functions, for example, RNA 7-methylguanosine cap binding,NOT RNA binding,RNA cap binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NCBP2 itself. We selected most functions NCBP2 had, and list some proteins which have the same functions with NCBP2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nucleotide binding | INSRA,CSNK1G2B,RHOUB,PSMC1B,PRKACBB,SLKA,ACTR1,TYMS,ATP8B5,KIAA0430 |
| snRNA binding | HEXIM1,SNRNP35,RBPMS,CDK9,HEXIM2,CCNT1 |
| RNA cap binding | EIF4A1,EIF4E,LARP1,SNUPN,NCBP1,EIF4E2,EIF4G3 |
| protein binding | PDIA3,SETD8,RNF165,NRXN1,ATP6V0A2,CD1d1,TRAF3IP2,KIAA1279,TOMM7,BCKDHA |
| RNA 7-methylguanosine cap binding | EIF4EA,AGO2,DCPS |
| poly(A) RNA binding | SNRPD1,NAP1L1,EIF1,ASCC3,HNRNPH2,RPL37A,YTHDF3,DHX15,EXOSC7,OASL1 |
| NOT RNA binding | RNPS1 |
| mRNA binding | HNRNPAB,CSTF2T,TPR,SNRNP35,PAIP2,FMR1,EIF4A1,RBFOX2,G3BP1,RPS26 |
Interacting Protein
NCBP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NCBP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NCBP2.
NCBP1;LZTS2;IKBKE;SF3A2;q7cg32_yerpe;TARSL2;MYH7B;7mgppp;RPL10;ZBTB48;KPNA3
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